Varied cognitive dysfunctions including memory, attention, inputs, processing and filtration have been found in insomnia. Meanwhile, evidence from functional neuroimaging have revealed that the abnormal metabolism in prefrontal cortex was associated with probable deficit of executive function. And in our study, we have detected the response inhibition in insomnia patients by Go/NoGo,an Event-related potentials (ERPs) study, in order to explore the impaired executive function, because response inhibition is a hallmark of executive function.We used polysomnography (PSG) to record such objective PSG parameters. Go/NoGo was performed in sequence, different ERP components have been analyzed such as latency or amplitude between insomnia group and control group. And we used Person correlation coefficient R to make analysis between different ERP components and gender, duration, education, BMI and sleep characteristics.On the behavioral level, we found a little poor performance insomnia participants. On the electrophysiological level, under Go condition, insomnia participants have prolonged latency and smaller amplitude of N2 or P3. While, under NoGo condition, insomnia participants also have longer latency, but higher amplitude of N2 or P3. another major finding was that different correlation was found between gender,anxiety-depression,duration, education,BMI,sleep characteristics and N2 or P3.Our study has revealed that sleep loss may influence the response inhibition ability in insomnia, not only on behavior level, but also on the electrophysiological level. Abnormal changes in inhibition process or inhibition supervision can be represented as N2/P3 components under Go/No-go condition. Additionally, correlation analysis has been found between gender, anxiety-depression, BMI, education, and sleep structure. Thus, sleep loss attenuates response inhibition and impairs executive function in insomnia participants.Copyright © 2022. Published by Elsevier B.V.