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Cerebellum drives functional dysfunctions in restless leg syndrome

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机构： [1]College of Electrical Engineering, Sichuan University, Chengdu, China [2]Med-X Center for Informatics, Sichuan University, Chengdu, China [3]State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China [4]Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan, China [5]Medical School, Kunming University of Science and Technology, Kunming, China [6]Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China [7]College of Biomedical Engineering, Sichuan University, Chengdu, China [8]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [9]Beijing Key Laboratory of Neuromodulation, Beijing, China

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关键词： Restless legs syndrome Dynamic Amplitude of low frequency fluctuation Functional connectivity Granger causality analysis

摘要：

Restless legs syndrome (RLS) has serious effects on patients' sleep quality, physical and mental health. However, the pathophysiological mechanisms of RLS remain unclear. This study utilized both static and dynamic functional activity and connectivity analyses approaches as well as effective connectivity analysis to reveal the neurophysiological basis of RLS.The resting-state functional MRI (rs-fMRI) data from 32 patients with RLS and 33 age-, and gender-matched healthy control (HC) were collected. Dynamic and static amplitude of low frequency fluctuation (ALFF), functional connectivity (FC), and Granger causality analysis (GCA) were employed to reveal the abnormal functional activities and couplings in patients with RLS.RLS patients showed over-activities in left parahippocampus and right cerebellum, hyper-connectivities of right cerebellum with left basal ganglia, left postcentral gyrus and right precentral gyrus, and enhanced effective connectivity from right cerebellum to left postcentral gyrus compared to HC.Abnormal cerebellum-basal ganglia-sensorimotor cortex circuit may be the underlying neuropathological basis of RLS. Our findings highlight the important role of right cerebellum in the onset of RLS and suggest right cerebellum may be a potential target for precision therapy.Copyright © 2023. Published by Elsevier B.V.

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出版当年[2022]版：

大类 | 2 区医学

小类 | 3 区临床神经病学

最新[2025]版：

大类 | 2 区医学

小类 | 3 区临床神经病学

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出版当年[2021]版：

Q2 CLINICAL NEUROLOGY

最新[2023]版：

Q1 CLINICAL NEUROLOGY

影响因子： 3.8 最新[2023版] 4 最新五年平均 4.842 出版当年[2021版] 4.991 出版当年五年平均 3.492 出版前一年[2020版] 4.8 出版后一年[2022版]

第一作者：

第一作者机构： [1]College of Electrical Engineering, Sichuan University, Chengdu, China [2]Med-X Center for Informatics, Sichuan University, Chengdu, China

通讯作者：

通讯机构： [3]State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China [4]Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan, China [8]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [9]Beijing Key Laboratory of Neuromodulation, Beijing, China [*1]State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China. [*2]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

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Cerebellum drives functional dysfunctions in restless leg syndrome

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