个人科研网厅 | | 帮助
首都医科大学宣武医院知识库
高级检索
当前位置： 首页 > 详情页

Glutamine supplementation alleviated aortic atherosclerosis in mice model and in vitro

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Zhang Hao[1] * ; Wang Chunxiu[2] * ; Sun Haichen[3] ; Zhou Tian[1] ; Ma Chang[1] ; Han Xuexue[1] ; Zhang Tianxing[1] ; Xia Jinggang[1,*1] ;
机构： [1]Department of Cardiology, National Clinical Research Centre for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Department of Evidence-Based Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China. [3]Surgical Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China.
出处：
DOI： 10.1002/pmic.202300179
ISSN：

关键词： atherosclerosis glutamine glycolysis inflammation O-GlcNAc oxidative stress

摘要：
This study aimed to clarify the role of glutamine in atherosclerosis and its participating mechanism. Forty C57BL/6J mice were divided into wild control (wild Con), ApoE- /- control (ApoE- /- Con), glutamine + ApoE- /- control (Glut + ApoE- /- Con), ApoE- /- high fat diet (ApoE- /- HFD), and glutamine + ApoE- /- HFD (Glut + ApoE- /- HFD) groups. The degree of atherosclerosis, western blotting, and multiomics were detected at 18 weeks. An in vitro study was also performed. Glutamine treatment significantly decreased the degree of aortic atherosclerosis (p = 0.03). O-GlcNAcylation (O-GlcNAc), IL-1β, IL-1α, and pyruvate kinase M2 (PKM2) in the ApoE- /- HFD group were significantly higher than those in the ApoE- /- Con group (p < 0.05). These differences were attenuated by glutamine treatment (p < 0.05), and aggravated by O-GlcNA transferase (OGT) overexpression in the in vitro study (p < 0.05). Multiomics showed that the ApoE- /- HFD group had higher levels of oxidative stress regulatory molecules (guanine deaminase [GUAD], xanthine dehydrogenase [XDH]), proinflammatory regulatory molecules (myristic acid and myristoleic acid), and stress granules regulatory molecules (caprin-1 and deoxyribose-phosphate aldolase [DERA]) (p < 0.05). These differences were attenuated by glutamine treatment (p < 0.05). We conclude that glutamine supplementation might alleviate atherosclerosis through downregulation of O-GlcNAc, glycolysis, oxidative stress, and proinflammatory pathway.© 2023 Wiley-VCH GmbH.

基金：
National Clinical Research Centre for Geriatric Diseases
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 4 区 生物学
小类 | 4 区 生化研究方法 4 区 生化与分子生物学
最新[2025]版：
大类 | 3 区 生物学
小类 | 3 区 生化研究方法 4 区 生化与分子生物学
JCR分区：
出版当年[2022]版：
Q2 BIOCHEMICAL RESEARCH METHODS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q2 BIOCHEMICAL RESEARCH METHODS Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Department of Cardiology, National Clinical Research Centre for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Cardiology, National Clinical Research Centre for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China. [*1]Department of Cardiology, National Clinical Research Centre for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Zhang Hao,Wang Chunxiu,Sun Haichen,et al.Glutamine supplementation alleviated aortic atherosclerosis in mice model and in vitro[J].PROTEOMICS.2024,24(5):doi:10.1002/pmic.202300179.
APA：
Zhang Hao,Wang Chunxiu,Sun Haichen,Zhou Tian,Ma Chang...&Xia Jinggang.(2024).Glutamine supplementation alleviated aortic atherosclerosis in mice model and in vitro.PROTEOMICS,24,(5)
MLA：
Zhang Hao,et al."Glutamine supplementation alleviated aortic atherosclerosis in mice model and in vitro".PROTEOMICS 24..5(2024)

相关文献

[1]Lipid metabolism and oxidative stress in patients with Alzheimer's disease and amnestic mild cognitive impairment [2]Increased inflammation, endoplasmic reticulum stress and oxidative stress in endothelial and macrophage cells exacerbate atherosclerosis in ApoCIII transgenic mice [3]Lipid metabolism and oxidative stress in patients with Alzheimer&apos;s disease and amnestic mild cognitive impairment [4]n-3 fatty acids modulate adipose tissue inflammation and oxidative stress [5]MicroRNA-146a protects against intracerebral hemorrhage by inhibiting inflammation and oxidative stress. [6]Trimetazidine Protects against Smoking-Induced Left Ventricular Remodeling via Attenuating Oxidative Stress, Apoptosis, and Inflammation [7]高龄冠心病伴房颤患者hs-CRP、Hcy和颈动脉粥样硬化的检测及意义 [8]ROS-Induced Endothelial Dysfunction in the Pathogenesis of Atherosclerosis [9]Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity by suppressing inflammation and oxidative stress [10]Tremella fuciformis Polysaccharides Attenuate Oxidative Stress and Inflammation in Macrophages through miR-155

资源点击量：17009 今日访问量：0 总访问量：906 更新日期：2025-04-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持：重庆聚合科技有限公司 地址：北京市西城区长椿街45号宣武医院