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Fibroblast subtypes in pancreatic cancer and pancreatitis: from mechanisms to therapeutic strategies

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收录情况： ◇ SCIE

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机构： [1]Department of Gastroenterology, Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Nanjing Medical University, Shanghai, China [2]Center for Biomarker Discovery and Validation, National Infrastructures for Translational Medicine (PUMCH), Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China [3]State Key Laboratory of Complex, Severe, and Rare Diseases, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China [4]Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China

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关键词： Cancer-associated fibroblast Subtypes of fibroblasts Pancreatic fibrosis Tumor microenvironment

摘要：

Excessive fibrosis is a predominant feature of pancreatic stroma and plays a crucial role in the development and progression of pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). Emerging evidence showed diversity and heterogeneity of fibroblasts play crucial and somewhat contradictory roles, the interactions between fibroblasts and pancreatic cells or infiltrating immune cells are of great importance during PDAC and CP progression, with some promising therapeutic strategies being tested. Therefore, in this review, we describe the classification of fibroblasts and their functions in PDAC and pancreatitis, the mechanisms by which fibroblasts mediate the development and progression of PDAC and CP through direct or indirect interaction between fibroblast and pancreatic parenchymal cells, or by remodeling the pancreatic immune microenvironment mediates the development and progression of PDAC and CP. Finally, we summarized the current therapeutic strategies and agents that directly target subtypes of fibroblasts or interfere with their essential functions.© 2023. Springer Nature Switzerland AG.

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出版当年[2023]版：

大类 | 2 区医学

小类 | 2 区细胞生物学 2 区病理学 3 区肿瘤学

最新[2023]版：

大类 | 2 区医学

小类 | 2 区细胞生物学 2 区病理学 3 区肿瘤学

JCR分区：

出版当年[2022]版：

Q1 ONCOLOGY Q1 PATHOLOGY Q2 CELL BIOLOGY

最新[2023]版：

Q1 ONCOLOGY Q1 PATHOLOGY Q2 CELL BIOLOGY

影响因子： 4.9 最新[2023版] 5.2 最新五年平均 6.6 出版当年[2022版] 6.1 出版当年五年平均 7.051 出版前一年[2021版] 4.9 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Gastroenterology, Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Nanjing Medical University, Shanghai, China

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通讯机构： [2]Center for Biomarker Discovery and Validation, National Infrastructures for Translational Medicine (PUMCH), Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China [3]State Key Laboratory of Complex, Severe, and Rare Diseases, Institute of Clinical Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China

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