Repetitive transcranial magnetic stimulation (rTMS) and cognitive training for patients with Alzheimer's disease (AD) can change functional connectivity (FC) within gray matter (GM). However, the role of white matter (WM) and changes of GM-WM FC under these therapies are still unclear. To clarify this problem, we applied 40 Hz rTMS over angular gyrus (AG) concurrent with cognitive training to 15 mild-moderate AD patients and analyzed the resting-state functional magnetic resonance imaging before and after treatment. Through AG-based FC analysis, corona radiata and superior longitudinal fasciculus (SLF) were identified as activated WM tracts. Compared with the GM results with AG as seed, more GM regions were found with activated WM tracts as seeds. The averaged FC, fractional amplitude of low-frequency fluctuation (fALFF), and regional homogeneity (ReHo) of the above GM regions had stronger clinical correlations (r/P = 0.363/0.048 vs 0.299/0.108, 0.351/0.057 vs 0.267/0.153, 0.420/0.021 vs 0.408/0.025, for FC/fALFF/ReHo, respectively) and better classification performance to distinguish pre-/post-treatment groups (AUC = 0.91 vs 0.88, 0.65 vs 0.63, 0.87 vs 0.82, for FC/fALFF/ReHo, respectively). Our results indicated that rTMS concurrent with cognitive training could rewire brain network by enhancing GM-WM FC in AD, and corona radiata and SLF played an important role in this process.
基金：
National Key Research and Development Program of China [2022YFC2402205]; NSFC Projects of International Cooperation and Exchanges [82211530041]; Capital's Funds for Health Improvement and Research [CFH2022-2-2014]; Shanghai Science and Technology Development Funds [22YF1413900]; National Natural Science Foundation of China [62206165, 82020108013]; Discipline Construction of Pudong New Area Health Commission [PWZxk2022-03]
第一作者机构：[1]Capital Med Univ, Xuanwu Hosp, Dept Urol, 45 Changchun St, Beijing 100053, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Capital Med Univ, Xuanwu Hosp, Dept Urol, 45 Changchun St, Beijing 100053, Peoples R China[*1]Department of Neurology, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Qin Tong,Wang Luyao,Xu Huanyu,et al.rTMS concurrent with cognitive training rewires AD brain by enhancing GM-WM functional connectivity: a preliminary study[J].CEREBRAL CORTEX.2024,34(1):doi:10.1093/cercor/bhad460.
APA：
Qin, Tong,Wang, Luyao,Xu, Huanyu,Liu, Chunyan,Shao, Yuxuan...&Lin, Hua.(2024).rTMS concurrent with cognitive training rewires AD brain by enhancing GM-WM functional connectivity: a preliminary study.CEREBRAL CORTEX,34,(1)
MLA：
Qin, Tong,et al."rTMS concurrent with cognitive training rewires AD brain by enhancing GM-WM functional connectivity: a preliminary study".CEREBRAL CORTEX 34..1(2024)
