Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS)
机构：[1]Department of Neurosurgery, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada[2]Neurology Center of Toronto by Numinus, Toronto, Ontario, Canada[3]Division of Pediatric Neurosurgery, Sick Kids Toronto, University of Toronto, Toronto, Ontorio, Canada[4]Department of Neurosurgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA[5]Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, USA[6]Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA[7]Department of Functional Neurosurgery, Xiamen Humanity Hospital, Xiamen, China[8]Department of Pediatric Epilepsy Center, Peking University First Hospital, Beijing, China[9]Department of Epilepsy Center, Yuquan Hospital, Tsinghua University, Beijing, China[10]Department of Neurological Surgery, St. Louis Children's Hospital, St. Louis, Missouri, USA[11]Department of Neurosurgery, Children's Hospital Colorado, Aurora, Colorado, USA[12]Division of Neurosurgery, Department of Pediatric Surgery, McGill University Health Centre, Montreal Children's Hospital, Montreal, Quebec, Canada[13]Department of Neurosurgery, Nicklaus Children's Hospital, Miami, Florida, USA[14]Department of Neurosurgery, University Medical Center Freiburg & Medical Faculty, University of Freiburg, Freiburg, Germany[15]Department of Neuropediatrics, University Children's Hospital Zurich, Zurich, Switzerland[16]Department of Neurosurgery, Medical University Vienna, Vienna, Austria[17]Department of Pediatrics, Medical University Vienna and ERN EpiCare, Vienna, Austria[18]Division of Pediatric Neurosurgery, Department of Neurosurgery, Primary Children's Hospital, Salt Lake City, Utah, USA[19]Department of Functional Neurosurgery, Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统神经外科功能神经外科首都医科大学宣武医院[20]Division of Neurosurgery, Department of Surgery, BC Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada[21]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院[22]Division of Pediatric Neurosurgery, Department of Surgery, Hassenfeld Children's Hospital, NYU Langone Health, New York, New York, USA[23]Department of Neurosurgery, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA[24]Division of Child Neurology and Epilepsy, Mayo Clinic College of Medicine, Rochester, Minnesota, USA[25]Division of Neurology, Department of Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, Quebec, Canada[26]Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India[27]Department of Neurosurgery (COE for Epilepsy & Magnetoencephalography), All India Institute of Medical Sciences and National Brain Research Center, New Delhi, India[28]Division of Neurosurgery, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada[29]Department of Neurosurgery, Guangdong Shenzhen Children Hospital, Shenzhen, Guangdong, China深圳市儿童医院深圳市康宁医院深圳医学信息中心[30]Department of Neurosurgery, Guangdong Sanjiu Brain Hospital, Guangzhou Shi, Guangdong Sheng, China[31]Department of Neurosurgery, Niño Jesus University Children's Hospital, Madrid, Spain[32]Department of Neurophysiology, Niño Jesus University Children's Hospital, Madrid, Spain[33]Department of Neurosurgery, Brussels Saint-Luc University Hospital, Brussels, Belgium[34]Department of Clinical Neurosciences, Division of Neurosurgery, Hospitaux Universitaire Genève, Genève, Switzerland[35]Department of Neurosurgery, Kantonsspital St.Gallen, Medical School of St.Gallen, St.Gallen, Switzerland[36]Pediatric and Functional Neurosurgery, Department of Neurosciences, University of Padova, Padova, Italy[37]Department of Neurosurgery, Pontificia Universidad Catolica de Chile, Hospital Sotero del Rio, Santiago, Región Metropolitana, Chile[38]Epilepsy Department, Neurologia Neurofisiologia Servicio de Epilepsia FLENI, Buenos Aires, Argentina[39]Department of Neurosurgery, Brandenburg Medical School, University Hospital Ruppin-Brandenburg, Neuruppin, Germany[40]Department of Neurosurgery, Neurosurgical Clinic, Bochum, Germany[41]Department of Neurosurgery, Children's National Medical Center, Washington, DC, USA[42]Divisions of Child Neurology and Epilepsy and Neurophysiology, Children's National Hospital, Washington, DC, USA[43]Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Alfaisal University, Riyadh, Saudi Arabia[44]Department of Neurosurgery, University Hospital Zurich & Clinical Neuroscience Center, University of Zurich, Zurich, Switzerl[45]Department of Neurology, Boston Children's Hospital, Boston, Massachusetts, USA
ObjectivesAlthough hemispheric surgeries are among the most effective procedures for drug-resistant epilepsy (DRE) in the pediatric population, there is a large variability in seizure outcomes at the group level. A recently developed HOPS score provides individualized estimation of likelihood of seizure freedom to complement clinical judgement. The objective of this study was to develop a freely accessible online calculator that accurately predicts the probability of seizure freedom for any patient at 1-, 2-, and 5-years post-hemispherectomy.MethodsRetrospective data of all pediatric patients with DRE and seizure outcome data from the original Hemispherectomy Outcome Prediction Scale (HOPS) study were included. The primary outcome of interest was time-to-seizure recurrence. A multivariate Cox proportional-hazards regression model was developed to predict the likelihood of post-hemispheric surgery seizure freedom at three time points (1-, 2- and 5- years) based on a combination of variables identified by clinical judgment and inferential statistics predictive of the primary outcome. The final model from this study was encoded in a publicly accessible online calculator on the International Network for Epilepsy Surgery and Treatment (iNEST) website ().ResultsThe selected variables for inclusion in the final model included the five original HOPS variables (age at seizure onset, etiologic substrate, seizure semiology, prior non-hemispheric resective surgery, and contralateral fluorodeoxyglucose-positron emission tomography [FDG-PET] hypometabolism) and three additional variables (age at surgery, history of infantile spasms, and magnetic resonance imaging [MRI] lesion). Predictors of shorter time-to-seizure recurrence included younger age at seizure onset, prior resective surgery, generalized seizure semiology, FDG-PET hypometabolism contralateral to the side of surgery, contralateral MRI lesion, non-lesional MRI, non-stroke etiologies, and a history of infantile spasms. The area under the curve (AUC) of the final model was 73.0%.SignificanceOnline calculators are useful, cost-free tools that can assist physicians in risk estimation and inform joint decision-making processes with patients and families, potentially leading to greater satisfaction. Although the HOPS data was validated in the original analysis, the authors encourage external validation of this new calculator.
第一作者机构：[1]Department of Neurosurgery, Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada
通讯作者：
通讯机构：[4]Department of Neurosurgery, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA[*1]Department of Neurosurgery and Pediatrics, David Geffen School of Medicine at UCLA, UCLA Mattel Children's Hospital, 300 Stein Plaza, Suite #525, Los Angeles, CA 90095-6901, USA.
推荐引用方式(GB/T 7714)：
Alexander G. Weil,Evan Dimentberg,Evan Lewis,et al.Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS)[J].EPILEPSIA.2024,65(1):46-56.doi:10.1111/epi.17689.
APA：
Alexander G. Weil,Evan Dimentberg,Evan Lewis,George M. Ibrahim,Olivia Kola...&Aria Fallah.(2024).Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS).EPILEPSIA,65,(1)
MLA：
Alexander G. Weil,et al."Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS)".EPILEPSIA 65..1(2024):46-56
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