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Comparison of the real-world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug-resistant epilepsy: A post hoc analysis of the HOPS study

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收录情况： ◇ SCIE

作者：
Aria Fallah[1] * ; Evan Lewis[2] ; George M. Ibrahim[3] ; Olivia Kola[1] ; Chi-­Hong Tseng[4] ; William B. Harris[5] ; Jia-­Shu Chen[6] ; Kao-­Min Lin[7] ; Li-­Xin Cai[8] ; Qing-­Zhu Liu[8] ; Jiu-­Luan Lin[9] ; Wen-­Jing Zhou[9] ; Gary W. Mathern[1] ; Matthew D. Smyth[10] ; Brent R. O‘Neill[11] ; Roy W. R. Dudley[12] ; John Ragheb[13] ; Sanjiv Bhatia[13] ; Daniel Delev[14] ; Georgia Ramantani[14,15] ; Josef Zentner[14] ; Anthony C. Wang[1] ; Christian Dorfer[16] ; Martha Feucht[17] ; Thomas Czech[16] ; Robert J. Bollo[18] ; Galymzhan Issabekov[19] ; Hongwei Zhu[19] ; Mary Connolly[20] ; Paul Steinbok[20] ; Jian-­Guo Zhang[21] ; Kai Zhang[21] ; Eveline Teresa Hidalgo[22] ; Howard L. Weiner[23] ; Lily Wong-­Kisiel[24] ; Samuel Lapalme-­Remis[25] ; Manjari Tripathi[26] ; Poodipedi SaratChandra[27] ; Walter Hader[28] ; Feng-­Peng Wang[7] ; Yi Yao[29] ; Pierre-­Olivier Champagne[30] ; Tristan Brunette-­Clément[30] ; Qiang Guo[31] ; Shao-­Chun Li[31] ; Marcelo Budke[32] ; Maria Angeles Pérez-­Jiménez[33] ; Christian Raftopoulos[34] ; Patrice Finet[34] ; Pauline Michel[34] ; Karl Schaller[35] ; Martin N. Stienen[36] ; Valentina Baro[37] ; Christian Cantillano Malone[38] ; Juan Pociecha[39] ; Noelia Chamorro[39] ; Valeria L. Muro[39] ; Marec von Lehe[40] ; Silvia Vieker[40] ; Chima Oluigbo[41] ; William D. Gaillard[42] ; Mashael Al-­Khateeb[43] ; Faisal Al Otaibi[43] ; Niklaus Krayenbühl[36] ; Jeffrey Bolton[44] ; Phillip L. Pearl[44] ; Alexander G. Weil[30,*1] ;
机构： [1]Department of Neurosurgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA [2]Neurology Center of Toronto, Toronto, Ontario, Canada [3]Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada [4]Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA [5]Department of Medicine, John A. Burns School of Medicine at University of Hawaii, Honolulu, Hawaii, USA [6]Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA [7]Department of Functional Neurosurgery, Xiamen Humanity Hospital, Xiamen, China [8]Department of Pediatric Epilepsy Center, Peking University First Hospital, Beijing, China [9]Department of Epilepsy Center, Yuquan Hospital, Tsinghua University, Beijing, China [10]Department of Neurological Surgery, St. Louis Children‘s Hospital, St. Louis, Missouri, USA [11]Department of Neurosurgery, Children‘s Hospital Colorado, Aurora, Colorado, USA [12]Division of Neurosurgery, Department of Pediatric Surgery, Montreal Children‘s Hospital, McGill University Health Centre, Montreal, Quebec, Canada [13]Department of Neurosurgery, Nicklaus Children‘s Hospital, Miami, Florida, USA [14]Department of Neurosurgery, University Medical Center Freiburg and Medical Faculty, University of Freiburg, Freiburg, Germany [15]Department of Neuropediatrics, University Children‘s Hospital Zurich, Zurich, Switzerland [16]Department of Neurosurgery, Medical University Vienna, Vienna, Austria [17]Department of Pediatrics, Medical University Vienna, Vienna, Austria [18]Division of Pediatric Neurosurgery, Department of Neurosurgery, Primary Children‘s Hospital, Salt Lake City, Utah, USA [19]Department of Functional Neurosurgery, Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [20]Division of Neurosurgery, Department of Surgery, BC Children‘s Hospital and University of British Columbia, Vancouver, British Columbia, Canada [21]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China [22]Division of Pediatric Neurosurgery, Department of Surgery, Hassenfeld Children‘s Hospital, NYU Langone Health, New York, New York, USA [23]Baylor College of Medicine, Texas Children‘s Hospital, Houston, Texas, USA [24]Division of Child Neurology and Epilepsy, Mayo Clinic College of Medicine, Rochester, Minnesota, USA [25]Division of Neurology, Department of Medicine, University of Montreal Hospital Centre, Montreal, Quebec, Canada [26]Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India [27]Department of Neurosurgery (Center of Excellence for Epilepsy & Magnetoencephalography), All India Institute of Medical Sciences and NationalBrain Research Center, New Delhi, India [28]Division of Neurosurgery, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada [29]Department of Neurosurgery, Guangdong Shenzhen Children Hospital, Shenzhen, China [30]Department of Neurosurgery, Saint Justine University Hospital Centre, Montreal, Quebec, Canada [31]Department of Neurosurgery, Guangdong Sanjiu Brain Hospital, Guangzhou Shi, China [32]Department of Neurosurgery, Niño Jesus University Children‘s Hospital, Madrid, Spain [33]Department of Neurophysiology, Niño Jesus University Children‘s Hospital, Madrid, Spain [34]Department of Neurosurgery, Brussels Saint-Luc University Hospital, Brussels, Belgium [35]Division of Neurosurgery, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland [36]Department of Neurosurgery, University Hospital Zurich and Clinical Neuroscience Center, University of Zurich, Zurich, Switzerland [37]Academic Neurosurgery, Department of Neuroscience, University of Padova, Padova, Italy [38]Department of Neurosurgery, Pontifical Catholic University of Chile, Sotero del Rio Hospital, Santiago, Chile [39]Epilepsy Department, Neurology Neurophysiology Epilepsy Service Foundation Against Childhood Neurological Diseases, Buenos Aires, Argentina [40]Department of Neurosurgery, Brandenburg Medical School, Neuruppin, Germany [41]Department of Neurosurgery, Children‘s National Medical Center, Washington, District of Columbia, USA [42]Divisions of Child Neurology and Epilepsy and Neurophysiology, Children‘s National Medical Center, Washington, District of Columbia, USA [43]Department of Neurosciences, King Faisal Specialist Hospital and Research Center, Alfaisal University, Riyadh, Saudi Arabia [44]Department of Neurology, Boston Children‘s Hospital, Boston, Massachusetts, USA
出处：
DOI： 10.1111/epi.17021
ISSN：

关键词： hemispherectomy hemispherotomy seizure outcomes technique

摘要：
Objective This study was undertaken to determine whether the vertical parasagittal approach or the lateral peri-insular/peri-Sylvian approach to hemispheric surgery is the superior technique in achieving long-term seizure freedom. Methods We conducted a post hoc subgroup analysis of the HOPS (Hemispheric Surgery Outcome Prediction Scale) study, an international, multicenter, retrospective cohort study that identified predictors of seizure freedom through logistic regression modeling. Only patients undergoing vertical parasagittal, lateral peri-insular/peri-Sylvian, or lateral trans-Sylvian hemispherotomy were included in this post hoc analysis. Differences in seizure freedom rates were assessed using a time-to-event method and calculated using the Kaplan-Meier survival method. Results Data for 672 participants across 23 centers were collected on the specific hemispherotomy approach. Of these, 72 (10.7%) underwent vertical parasagittal hemispherotomy and 600 (89.3%) underwent lateral peri-insular/peri-Sylvian or trans-Sylvian hemispherotomy. Seizure freedom was obtained in 62.4% (95% confidence interval [CI] = 53.5%-70.2%) of the entire cohort at 10-year follow-up. Seizure freedom was 88.8% (95% CI = 78.9%-94.3%) at 1-year follow-up and persisted at 85.5% (95% CI = 74.7%-92.0%) across 5- and 10-year follow-up in the vertical subgroup. In contrast, seizure freedom decreased from 89.2% (95% CI = 86.3%-91.5%) at 1-year to 72.1% (95% CI = 66.9%-76.7%) at 5-year to 57.2% (95% CI = 46.6%-66.4%) at 10-year follow-up for the lateral subgroup. Log-rank test found that vertical hemispherotomy was associated with durable seizure-free progression compared to the lateral approach (p = .01). Patients undergoing the lateral hemispherotomy technique had a shorter time-to-seizure recurrence (hazard ratio = 2.56, 95% CI = 1.08-6.04, p = .03) and increased seizure recurrence odds (odds ratio = 3.67, 95% CI = 1.05-12.86, p = .04) compared to those undergoing the vertical hemispherotomy technique. Significance This pilot study demonstrated more durable seizure freedom of the vertical technique compared to lateral hemispherotomy techniques. Further studies, such as prospective expertise-based observational studies or a randomized clinical trial, are required to determine whether a vertical approach to hemispheric surgery provides superior long-term seizure outcomes.

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中科院(CAS)分区：
出版当年[2020]版：
大类 | 2 区 医学
小类 | 2 区 临床神经病学
最新[2023]版：
大类 | 1 区 医学
小类 | 2 区 临床神经病学
JCR分区：
出版当年[2019]版：
Q1 CLINICAL NEUROLOGY
最新[2023]版：
Q1 CLINICAL NEUROLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Department of Neurosurgery, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA
通讯作者：
通讯机构： [30]Department of Neurosurgery, Saint Justine University Hospital Centre, Montreal, Quebec, Canada [*1]Division of Neurosurgery, Ste. Justine Hospital,3175 Chemin de la Côte-SainteCatherine, Montréal, Québec H3T 1C5,Canada
推荐引用方式(GB/T 7714)：
Aria Fallah,Evan Lewis,George M. Ibrahim,et al.Comparison of the real-world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug-resistant epilepsy: A post hoc analysis of the HOPS study[J].EPILEPSIA.2021,62(11):2707-2718.doi:10.1111/epi.17021.
APA：
Aria Fallah,Evan Lewis,George M. Ibrahim,Olivia Kola,Chi-­Hong Tseng...&Alexander G. Weil.(2021).Comparison of the real-world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug-resistant epilepsy: A post hoc analysis of the HOPS study.EPILEPSIA,62,(11)
MLA：
Aria Fallah,et al."Comparison of the real-world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug-resistant epilepsy: A post hoc analysis of the HOPS study".EPILEPSIA 62..11(2021):2707-2718

相关文献

[1]Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS) [2]Hemispheric surgery for refractory epilepsy: a systematic review and meta-analysis with emphasis on seizure predictors and outcomes [3]Hemispherectomy Outcome Prediction Scale: Development and validation of a seizure freedom prediction tool. [4]Seizure and cognitive outcomes of posterior quadrantic disconnection: a series of 12 pediatric patients. [5]Long-term follow-up seizure outcomes after corpus callosotomy: A systematic review with meta-analysis [6]Expression of RINT1 predicts seizure occurrence and outcomes in patients with low-grade gliomas [7]Treatment for patients with recurrent intractable epilepsy after primary hemispherectomy [8]解剖性大脑半球切除术后远期双上肢运动诱发电位的研究 [9]Rasmussen's syndrome and its treatment by hemispherectomy [10]Combined [F-18]FDG-PET with MRI structural patterns in predicting post-surgical seizure outcomes in temporal lobe epilepsy patients

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