Vascular fibrosis is a widespread pathologic condition that arises during vascular remodeling in cardiovascular dysfunctions. According to previous studies, vascular fibrosis is characterized by endothelial matrix deposition and vascular wall thickening. The RAAS and TGF-beta/Smad signaling pathways have been frequently highlighted. It is, however, far from explicit in terms of understanding the cause and progression of vascular fibrosis. In this review, we collected and categorized a large number of molecules which influence the fibrosing process, in order to acquire a better understanding of vascular fibrosis, particularly of pathologic dysfunction. Furthermore, several mediators that prevent vascular fibrosis are discussed in depth in this review, with the aim that this will contribute to the future prevention and treatment of related conditions. [GRAPHICAL ABSTRACT]
基金：
National Natural Science
Foundation of China Grant (No. 82174056 JDX).
第一作者机构：[1]Capital Med Univ, Sch Basic Med Sci, Dept Clin Med, Beijing, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Hua Rongxuan,Gao Han,He Chengwei,et al.An emerging view on vascular fibrosis molecular mediators and relevant disorders: from bench to bed[J].FRONTIERS IN CARDIOVASCULAR MEDICINE.2023,10:doi:10.3389/fcvm.2023.1273502.
APA：
Hua, Rongxuan,Gao, Han,He, Chengwei,Xin, Shuzi,Wang, Boya...&Xu, Jingdong.(2023).An emerging view on vascular fibrosis molecular mediators and relevant disorders: from bench to bed.FRONTIERS IN CARDIOVASCULAR MEDICINE,10,
MLA：
Hua, Rongxuan,et al."An emerging view on vascular fibrosis molecular mediators and relevant disorders: from bench to bed".FRONTIERS IN CARDIOVASCULAR MEDICINE 10.(2023)
