Aims: Most studies focus on dynamic cerebral autoregulation (dCA) in the middle cerebral artery (MCA), and few studies investigated neurovascular coupling (NVC) and dCA in the posterior cerebral artery (PCA). We investigated NVC and dCA of the PCA in healthy volunteers to identify sex differences. Methods: Thirty men and 30 age-matched women completed dCA and NCV assessments. The cerebral blood flow velocity (CBFV) and mean arterial pressure were evaluated using transcranial Doppler ultrasound and a servo-controlled plethysmograph, respectively. The dCA parameters were analyzed using transfer function analysis. The NCV was evaluated by eyes-open and eyes-closed (24 s each) periodically based on voice prompts. The eyes-open visual stimulation comprised silent reading of Beijing-related tourist information. Results: The PCA gain was lower than that of the MCA in all frequency ranges (all p < 0.05). Phase was consistent across the cerebrovascular territories. The cerebrovascular conductance index (CVCi) and mean CBFV (MV) of the PCA were significantly higher during the eyes-open than eyes-closed period (CVCi: 0.50 +/- 0.12 vs. 0.38 +/- 0.10; MV: 42.89 +/- 8.49 vs. 32.98 +/- 7.25, both p < 0.001). The PCA dCA and NVC were similar between the sexes. Conclusion: We assessed two major mechanisms that maintain cerebral hemodynamic stability in healthy men and women. The visual stimulation-evoked CBFV of the PCA was significantly increased compared to that during rest, confirming the activation of NVC. Men and women have similar functions in PCA dCA and NCV.
基金：
National Natural Science Foundation
cultivation project of Xuanwu Hospital,
Grant/Award Number:
NO. QNPY2022007
第一作者机构：[1]Capital Med Univ, Xuanwu Hosp, Dept Vasc Ultrasonog, Beijing, Peoples R China[2]Beijing Diagnost Ctr Vasc Ultrasound, Beijing, Peoples R China[3]Capital Med Univ, Beijing Inst Brain Disorders, Ctr Vasc Ultrasonog, Collaborat Innovat Ctr Brain Disorders, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Xuanwu Hosp, Dept Vasc Ultrasonog, Beijing, Peoples R China[2]Beijing Diagnost Ctr Vasc Ultrasound, Beijing, Peoples R China[3]Capital Med Univ, Beijing Inst Brain Disorders, Ctr Vasc Ultrasonog, Collaborat Innovat Ctr Brain Disorders, Beijing, Peoples R China[4]Capital Med Univ, Xuanwu Hosp, Dept Vasc Ultrasonog, 45 Changchun Rd, Beijing 100053, Peoples R China[5]Beijing Inst Brain Disorders, Beijing Diagnost Ctr Vasc Ultrasound, 45 Changchun Rd, Beijing 100053, Peoples R China
推荐引用方式(GB/T 7714)：
Chen Hongxiu,Cui Liuping,Chen Songwei,et al.Comparable dynamic cerebral autoregulation and neurovascular coupling of the posterior cerebral artery between healthy men and women[J].CNS NEUROSCIENCE & THERAPEUTICS.2024,30(2):doi:10.1111/cns.14584.
APA：
Chen, Hongxiu,Cui, Liuping,Chen, Songwei,Liu, Ran,Pan, Xijuan...&Xing, Yingqi.(2024).Comparable dynamic cerebral autoregulation and neurovascular coupling of the posterior cerebral artery between healthy men and women.CNS NEUROSCIENCE & THERAPEUTICS,30,(2)
MLA：
Chen, Hongxiu,et al."Comparable dynamic cerebral autoregulation and neurovascular coupling of the posterior cerebral artery between healthy men and women".CNS NEUROSCIENCE & THERAPEUTICS 30..2(2024)
