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Dynamic Cerebral Autoregulation in Preclinical Atherosclerotic Cardiovascular Disease

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机构： [1]Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Center of Vascular Ultrasonography, Beijing Institute of Brain Disorders, Beijing, China [3]Human Informatics Research Institute, National Institute of Advanced Industrial Science and Technology, Higashi, Tsukuba, Japan [4]Evidence-Based Medicine Center, Xuanwu Hospital, Capital Medical University, Beijing, China

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关键词： Atherosclerosis cardiovascular cerebral autoregulation transcranial Doppler

摘要：

Objective: The influence of atherosclerotic cardiovascular disease (ASCVD) on cerebral blood flow control is not well known. The aim of this study was to investigate the association between cardiovascular function and dynamic cerebral autoregulation (dCA) in patients with preclinical ASCVD. Methods: A total of 44 participants aged 26-76 years were divided into low- and high-risk groups according to the China assessment of ASCVD risk. The cardiac function was assessed by echocardiography. The beat-to-beat blood pressure and cerebral blood flow velocity were measured at rest. Spectral and transfer function analyses were used to calculate cerebral and systemic hemodynamic variability and to estimate dCA metrics. Results: There were no group differences in beat-to-beat heart rate, blood pressure, and cerebral blood flow velocity variability nor the ejection fraction, E/A and E’/A’. The dCA phase at very low frequency was reduced in the high-risk group (P =.03). Moreover, the dCA phase and E’/A’ were negatively correlated with age, and dCA phase was positively correlated with E’/A’ within the high-risk group (r2 =.517, P <.01). Conclusions: These findings suggest that advancing age, particularly in the high-risk ASCVD group, impairs cerebral blood flow control and cardiac diastolic function which are correlated with each other and may interplay under the effects of ASCVD risk factors. © 2020 Elsevier Inc.

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出版当年[2019]版：

大类 | 4 区医学

小类 | 4 区神经科学 4 区外周血管病

最新[2023]版：

大类 | 4 区医学

小类 | 4 区神经科学 4 区外周血管病

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出版当年[2018]版：

Q4 PERIPHERAL VASCULAR DISEASE Q4 NEUROSCIENCES

最新[2023]版：

Q3 NEUROSCIENCES Q3 PERIPHERAL VASCULAR DISEASE

影响因子： 2 最新[2023版] 2.1 最新五年平均 1.646 出版当年[2018版] 1.812 出版当年五年平均 1.598 出版前一年[2017版] 1.787 出版后一年[2019版]

第一作者：

第一作者机构： [1]Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Center of Vascular Ultrasonography, Beijing Institute of Brain Disorders, Beijing, China

通讯作者：

通讯机构： [1]Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, China [*1]Department of Vascular Ultrasonography, Xuanwu Hospital, The Capital Medical University, Beijing 100053, China [2]Center of Vascular Ultrasonography, Beijing Institute of Brain Disorders, Beijing, China

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