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Efficacy and safety of agomelatine in epilepsy patients with sleep and mood disorders: An observational, retrospective cohort study

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收录情况： ◇ SCIE

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机构： [1]Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P. R. China [2]Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P. R. China [3]Institute of Epilepsy, Shandong University, P. R. China [4]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China

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关键词： Epilepsy Depression Anxiety Sleep Disorders Agomelatine

摘要：

To evaluate the therapeutic efficacy and safety of agomelatine for treating the sleep and mood disorders in epilepsy patients.Retrospective data were derived from 113 epilepsy patients for at least 8 weeks. All the subjects were divided into two groups, one was treated with agomelatine, the other was treated with escitalopram. Their depression and anxiety states were assessed by Hamilton Depression (HAMD) and Hamilton Anxiety (HAMA) Scales. Sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI).The HAMA, HAMD and PSQI scores in both groups significantly declined after the treatments with agomelatine and escitalopram. However, the agomelatine group exhibited greater improvement in terms of HAMA and PSQI scores compared to the escitalopram group. No severe adverse events were observed in agomelatine group.Agomelatine performed better in HAMA and PSQI scores compared to escitalopram, where no significant increase in seizure frequency or side effects were observed. Possibly, agomelatine presents a promising therapeutic option for treating the sleep or mood disorders in epilepsy patients.Copyright © 2024. Published by Elsevier Inc.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区行为科学 3 区精神病学 4 区临床神经病学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区行为科学 3 区精神病学 4 区临床神经病学

JCR分区：

出版当年[2022]版：

Q2 BEHAVIORAL SCIENCES Q3 CLINICAL NEUROLOGY Q3 PSYCHIATRY

最新[2023]版：

Q2 PSYCHIATRY Q2 BEHAVIORAL SCIENCES Q3 CLINICAL NEUROLOGY

影响因子： 2.3 最新[2023版] 2.5 最新五年平均 2.6 出版当年[2022版] 2.7 出版当年五年平均 3.337 出版前一年[2021版] 2.3 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P. R. China [3]Institute of Epilepsy, Shandong University, P. R. China

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通讯作者：

通讯机构： [2]Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P. R. China [3]Institute of Epilepsy, Shandong University, P. R. China [4]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China

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