详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

The link between gut microbiome and Alzheimer's disease: From the perspective of new revised criteria for diagnosis and staging of Alzheimer's disease

22| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Neurology, The Affiliated Hospital of Jining Medical University, Jining, China. [2]Department of Respiratory Medicine, The Affiliated Hospital of Jining Medical University, Jining, China. [3]Department of Radiology, The People's Hospital of Yanzhou, Jining, China. [4]Department of Emergency, The Affiliated Hospital of Jining Medical University, Jining, China. [5]Department of Neurology, China-Japan Friendship Hospital, Beijing, China. [6]Department of Neurology, Sir Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. [7]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China. [8]Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou, China. [9]Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China. [10]National Clinical Research Center for Geriatric Disorders, Beijing, China.

出处：

DOI：

ISSN：

关键词： Alzheimer’s disease amyloid biomarker criteria gut microbiome inflammation neurodegeneration tau

摘要：

Over the past decades, accumulating evidence suggests that the gut microbiome exerts a key role in Alzheimer's disease (AD). The Alzheimer's Association Workgroup is updating the diagnostic criteria for AD, which changed the profiles and categorization of biomarkers from "AT(N)" to "ATNIVS." Previously, most of studies focus on the correlation between the gut microbiome and amyloid beta deposition ("A"), the initial AD pathological feature triggering the "downstream" tauopathy and neurodegeneration. However, limited research investigated the interactions between the gut microbiome and other AD pathogenesis ("TNIVS"). In this review, we summarize current findings of the gut microbial characteristics in the whole spectrum of AD. Then, we describe the association of the gut microbiome with updated biomarker categories of AD pathogenesis. In addition, we outline the gut microbiome-related therapeutic strategies for AD. Finally, we discuss current key issues of the gut microbiome research in the AD field and future research directions. HIGHLIGHTS: The new revised criteria for Alzheimer's disease (AD) proposed by the Alzheimer's Association Workgroup have updated the profiles and categorization of biomarkers from "AT(N)" to "ATNIVS." The associations of the gut microbiome with updated biomarker categories of AD pathogenesis are described. Current findings of the gut microbial characteristics in the whole spectrum of AD are summarized. Therapeutic strategies for AD based on the gut microbiome are proposed.© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版：

大类 | 1 区

医学

小类 | 1 区临床神经病学

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区临床神经病学

JCR分区：

出版当年[2022]版：

Q1 CLINICAL NEUROLOGY

最新[2023]版：

Q1 CLINICAL NEUROLOGY

影响因子： 13.1 最新[2023版] 16.1 最新五年平均 14 出版当年[2022版] 18 出版当年五年平均 16.655 出版前一年[2021版] 13.1 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Neurology, The Affiliated Hospital of Jining Medical University, Jining, China.

共同第一作者：

通讯作者：

通讯机构： [7]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China. [8]Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou, China. [9]Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China. [10]National Clinical Research Center for Geriatric Disorders, Beijing, China.

推荐引用方式(GB/T 7714)：

APA：

MLA：

The link between gut microbiome and Alzheimer's disease: From the perspective of new revised criteria for diagnosis and staging of Alzheimer's disease

文献详情

相关文献