详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Association of APOE-ε4 and GAP-43-related presynaptic loss with β-amyloid, tau, neurodegeneration, and cognitive decline

61| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China [2]Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, China [3]Department of Neurology, University of Chinese Academy of Sciences-Shenzhen Hospital, Shenzhen, China [4]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China [5]Institute of Biomedical Engineering, Peking University Shenzhen Graduate School, Shenzhen, China

出处：

DOI：

ISSN：

关键词： Alzheimer’s disease Apolipoprotein E Presynaptic loss Growth-associated protein-43 Neurodegeneration Cognition

摘要：

Apolipoprotein E-ε4 (APOE-ε4) carriers had elevated cerebrospinal fluid (CSF) presynaptic protein growth-associated protein-43 (GAP-43), but the underlying mechanism is not fully understood. We investigated how the APOE-ε4 genotype affects the baseline and longitudinal changes in CSF GAP-43 and their associations with β-amyloid positron emission tomography (Aβ PET), CSF phosphorylated tau 181 (p-Tau181), neurodegeneration, and cognitive decline. Compared to APOE-ε4 non-carriers, APOE-ε4 carriers had higher baseline levels and faster rates of increases in Aβ PET, CSF p-Tau181, and CSF GAP-43. Both higher baseline levels and faster rates of increase in CSF GAP-43 were associated with greater baseline Aβ PET and CSF p-Tau181, which fully mediated the APOE-ε4 effect on CSF GAP-43 elevations. Independent of Aβ PET and CSF p-Tau181, APOE-ε4 carriage was associated with exacerbated GAP-43-related longitudinal hippocampal atrophy and cognitive decline, especially in Aβ+ participants (GAP-43 × time × APOE-ε4). These findings suggest that the APOE-ε4 effect on GAP-43-related presynaptic dysfunction is mediated by primary Alzheimer's pathologies and independently correlates to hippocampal atrophy and cognitive decline in the future.Copyright © 2023 Elsevier Inc. All rights reserved.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2022]版：

大类 | 2 区

医学

小类 | 2 区神经科学 3 区老年医学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区老年医学 3 区神经科学

JCR分区：

出版当年[2021]版：

Q2 GERIATRICS & GERONTOLOGY Q2 NEUROSCIENCES

最新[2023]版：

Q2 GERIATRICS & GERONTOLOGY Q2 NEUROSCIENCES

影响因子： 3.7 最新[2023版] 4.1 最新五年平均 5.133 出版当年[2021版] 5.475 出版当年五年平均 4.673 出版前一年[2020版] 4.2 出版后一年[2022版]

第一作者：

第一作者机构： [1]Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China

通讯作者：

通讯机构： [1]Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China [5]Institute of Biomedical Engineering, Peking University Shenzhen Graduate School, Shenzhen, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

Association of APOE-ε4 and GAP-43-related presynaptic loss with β-amyloid, tau, neurodegeneration, and cognitive decline

文献详情

相关文献