机构：[1]Department of Evidence-based Medicine, Xuanwu Hospital of Capital Medical University, Beijing, China首都医科大学宣武医院循证医学中心[2]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China神经科系统神经内科首都医科大学宣武医院[3]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China[4]National Clinical Research Center for Geriatric Disorders, Beijing, China[5]Central Laboratory, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院中心实验室[6]Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany
Cognitive reserve (CR) and brain reserve (BR) could offer protective effects on cognition in the early stage of Alzheimer's disease (AD). However, the effects of CR or BR on cognition in individuals with subjective cognitive decline (SCD) are not clear.
To explore the effects of CR and BR on cognition in subjects with SCD.
We included 149 subjects from the Sino Longitudinal Study on Cognitive Decline (SILCODE) study. Education was used as a proxy for CR, and head circumference was used as a proxy for BR. Multiple linear regression models were conducted to examine the effects of CR and BR on cognitive scores. Furthermore, we assessed differences in effects between APOEɛ4 carriers with SCD (n = 35) and APOEɛ4 non-carriers with SCD (n = 114) and linear trends among 4 reserve levels (low BR/CR, high BR/low CR, low BR/high CR, and high BR/high CR).
Both CR and BR had independent positive effects on multiple cognitive measures in SCD participants, and the effects of CR were greater than those of BR. CR has positive effects on cognitive measures in both APOEɛ4 carriers and non-carriers with SCD. However, the positive effects of BR on cognitive measures were observed in APOEɛ4 non-carriers with SCD but not in APOEɛ4 carriers with SCD. Furthermore, there was a linear trend toward better cognitive performance on all cognitive measures in the BR+/CR+ group, followed by the BR-/CR+, BR+/CR-, and BR-/CR-groups.
This study suggests that both CR and BR have the potential to delay or slow cognitive decline in individuals with SCD.
基金：
This article was supported by The National
Key Research and Development Program of
China (2016YFC1306300, 2018YFC1312001),
National Natural Science Foundation of China
(61633018, 81801052, 81601454), Beijing
Municipal Commission of Health and Family
Planning (PXM2020 026283 000002), and China
Postdoctoral Science Foundation (2018M641414).
第一作者机构：[1]Department of Evidence-based Medicine, Xuanwu Hospital of Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing,China[*2]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
推荐引用方式(GB/T 7714)：
Yang Kun,Chen Guanqun,Sheng Can,et al.Cognitive Reserve, Brain Reserve, APOEɛ4, and Cognition in Individuals with Subjective Cognitive Decline in the SILCODE Study.[J].JOURNAL OF ALZHEIMERS DISEASE.2020,76(1):249-260.doi:10.3233/JAD-200082.
APA：
Yang Kun,Chen Guanqun,Sheng Can,Xie Yunyan,Li Yuxia...&Han Ying.(2020).Cognitive Reserve, Brain Reserve, APOEɛ4, and Cognition in Individuals with Subjective Cognitive Decline in the SILCODE Study..JOURNAL OF ALZHEIMERS DISEASE,76,(1)
MLA：
Yang Kun,et al."Cognitive Reserve, Brain Reserve, APOEɛ4, and Cognition in Individuals with Subjective Cognitive Decline in the SILCODE Study.".JOURNAL OF ALZHEIMERS DISEASE 76..1(2020):249-260
