机构：[1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China,神经科系统神经内科首都医科大学宣武医院[2]Department of Neurology, Zhejiang Taizhou Municipal Hospital, Taizhou, Zhejiang, China,[3]Department of Neurobiology, Xuanwu Hospital of Capital Medical University, Beijing, China,首都医科大学宣武医院[4]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China,[5]National Clinical Research Center for Geriatric Disorders, Beijing, China
Objective: This study assessed the methylation of peripheral NCAPH2 in individuals with subjective cognitive decline (SCD), identified its correlation with the hippocampal volume, and explored whether the correlation is influenced by apolipoprotein E epsilon 4 (APOE epsilon 4) status. Methods: Cognitively normal controls (NCs, n = 56), individuals with SCD (n = 81), and patients with objective cognitive impairment (OCI, n = 51) were included from the Sino Longitudinal Study on Cognitive Decline (NCT03370744). All participants completed neuropsychological assessments, blood tests, and structural MRI. NCAPH2 methylation was compared according to the diagnostic and APOE epsilon 4 status. Partial correlation analysis was conducted to assess the correlations between the hippocampal volume, cognitive tests, and the NCAPH2 methylation levels. Results: Individuals with SCD and patients with OCI showed significantly lower levels of NCAPH2 methylation than NCs, which were independent of the APOE epsilon 4 status. The NCAPH2 methylation levels and the hippocampal volumes were positively correlated in the SCD APOE epsilon 4 non-carriers but not in the OCI group. No association was found between the NCAPH2 methylation levels and the cognitive function. Conclusion: Abnormal changes in blood NCAPH2 methylation were found to occur in SCD, indicating its potential to be used as a useful peripheral biomarker in the early stage of Alzheimer's disease screening.
基金：
National Key Research and Development Program of China [2016YFC1306300]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [61633018, 82020108013]
第一作者机构：[1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China,[2]Department of Neurology, Zhejiang Taizhou Municipal Hospital, Taizhou, Zhejiang, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China,[4]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China,[5]National Clinical Research Center for Geriatric Disorders, Beijing, China
推荐引用方式(GB/T 7714)：
Chen Ying,Li Tao-Ran,Hao Shu-Wen,et al.Blood NCAPH2 Methylation Is Associated With Hippocampal Volume in Subjective Cognitive Decline With Apolipoprotein E epsilon 4 Non-carriers[J].FRONTIERS IN AGING NEUROSCIENCE.2021,13:632382.doi:10.3389/fnagi.2021.632382.
APA：
Chen, Ying,Li, Tao-Ran,Hao, Shu-Wen,Wang, Xiao-Ni,Cai, Yan-Ning&Han, Ying.(2021).Blood NCAPH2 Methylation Is Associated With Hippocampal Volume in Subjective Cognitive Decline With Apolipoprotein E epsilon 4 Non-carriers.FRONTIERS IN AGING NEUROSCIENCE,13,
MLA：
Chen, Ying,et al."Blood NCAPH2 Methylation Is Associated With Hippocampal Volume in Subjective Cognitive Decline With Apolipoprotein E epsilon 4 Non-carriers".FRONTIERS IN AGING NEUROSCIENCE 13.(2021):632382
