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Different baseline functional patterns of the frontal cortex in amyotrophic lateral sclerosis patients with Corticospinal tract hyperintensity

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机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, No.45, Changchun Street, Xicheng District, Beijing 100053, China [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, No.45, Changchun Street, Xicheng District, Beijing 100053, China [3]Department of Neurology, Xuanwu Hospital, Capital Medical University, No.45, Changchun Street, Xicheng District, Beijing 100053, China [4]Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, No. 5, Dewai Ankang Hutong, Xicheng District, Beijing 100088, China [5]Advanced Innovation Center for Human Brain Protection, Capital Medical University, No.45, Changchun Street, Xicheng District, Beijing 100053, China

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关键词： Amyotrophic Lateral Sclerosis Resting-state fMRI Amplitude of Low Frequency Fluctuations Functional Connectivity

摘要：

Nearly half of the amyotrophic lateral sclerosis (ALS) patients showed hyperintensity of the corticospinal tract (CST+), yet whether brain functional pattern differs between CST+and CST- patients remains obscure. In the current study, 19 ALS CST+, 41 ALS CST- patients and 37 healthy controls (HC) underwent resting state fMRI scans. We estimated local activity and connectivity patterns via the Amplitude of Low Frequency Fluctuations (ALFF) and the Network-Based Statistic (NBS) approaches respectively. The ALS CST+patients did not differ from the CST- patients in amyotrophic lateral sclerosis functional rating scale revised (ALSFRS-R) score and disease duration. ALFF of the superior frontal gyrus (SFG) and the inferior frontal gyrus pars opercularis (OIFG) were highest in the HC and lowest in the ALS CST- patients, resulting in significant group differences (PFWE<0.05). NBS analysis revealed a frontal network consisting of connections between SFG, OIFG, orbital frontal gyrus, middle cingulate cortex and the basal ganglia, which exhibited HC>ALS CST+ > ALS CST- group differences (PFWE=0.037) as well. The ALFF of the OIFG was significantly correlated with ALSFRS-R (R=0.34, P=0.028) and mean connectivity of the frontal network was trend-wise significantly correlated with disease duration (R=-0.31, P=0.052) in the ALS CST- patients. However, these correlations were insignificant in ALS CST+patients (P values > 0.8). In conclusion, The ALS CST+patients exhibited different patterns of baseline functional activity and connectivity in the frontal cortex which may indicate a functional compensatory effect.Copyright © 2024 Elsevier B.V. All rights reserved.

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出版当年[2023]版：

大类 | 4 区医学

小类 | 4 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区神经科学

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Q3 NEUROSCIENCES

最新[2023]版：

Q3 NEUROSCIENCES

影响因子： 2.7 最新[2023版] 2.9 最新五年平均 2.9 出版当年[2022版] 3.2 出版当年五年平均 3.61 出版前一年[2021版] 2.7 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, No.45, Changchun Street, Xicheng District, Beijing 100053, China [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, No.45, Changchun Street, Xicheng District, Beijing 100053, China

通讯作者：

通讯机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, No.45, Changchun Street, Xicheng District, Beijing 100053, China [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, No.45, Changchun Street, Xicheng District, Beijing 100053, China

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Different baseline functional patterns of the frontal cortex in amyotrophic lateral sclerosis patients with Corticospinal tract hyperintensity

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