机构：[1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院放射与核医学科医技科室[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China[3]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统神经内科首都医科大学宣武医院
The huge heterogeneity of the disease progression rate may cause inconsistent findings between local activity and functional connectivity of the primary sensorimotor area (PSMA) in amyotrophic lateral sclerosis (ALS). For illustration of this hypothesis, resting-state fMRI (RS-fMRI) data were collected and analyzed on 38 "definite" or "probable" ALS patients (19 fast and 19 slow, cut off median = 0.41) and 37 matched healthy controls. Amplitude of low frequency fluctuations (ALFFs) and functional connectivity strength (FCS) were analyzed within the PSMA. There was a decreased ALFF (p(FDR) <.05) and FCS (p = .022) in all ALS patients. The two metrics shared about 50% of variance (R = .7) and both showed significant positive correlation with ALS Functional Rating Scale-Revised (ALSFRS-R) in the fast (p values <.034) but not in the slow progression groups. Interestingly, when regressing out the ALFF, the PSMA network FCS, especially the inter-hemisphere FCS, showed negative correlation with the ALSFRS-R score in the slow (R = -.54, p = .026) but not the fast progression group. In summary, the current results suggest that RS-fMRI local activity and network functional connectivity accounts for the severity differently in the slow and fast progression ALS patients.
基金：
Beijing Hospitals Authority Youth Program [QML20190803]; Beijing Municipal Administration of Hospitals' Ascent Plan [DFL20180802]; Capital Health Development Research Project [2018-4-2015]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81801255, 82001352]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|2 区医学
小类|2 区神经科学2 区神经成像2 区核医学
最新[2023]版：
大类|2 区医学
小类|2 区神经成像2 区神经科学2 区核医学
JCR分区：
出版当年[2020]版：
Q1NEUROIMAGINGQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2NEUROSCIENCES
最新[2023]版：
Q1NEUROIMAGINGQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2NEUROSCIENCES
第一作者机构：[1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China[3]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China[*1]Department of Neurology, Xuanwu Hospital, Changchun Rd No.45, Beijing 100053, China[*2]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Changchun Rd No. 45, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Li Qianwen,Zhu Wenjia,Wen Xinmei,et al.Different sensorimotor mechanism in fast and slow progression amyotrophic lateral sclerosis[J].HUMAN BRAIN MAPPING.2022,43(5):1710-1719.doi:10.1002/hbm.25752.
APA：
Li, Qianwen,Zhu, Wenjia,Wen, Xinmei,Zang, Zhenxiang,Da, Yuwei&Lu, Jie.(2022).Different sensorimotor mechanism in fast and slow progression amyotrophic lateral sclerosis.HUMAN BRAIN MAPPING,43,(5)
MLA：
Li, Qianwen,et al."Different sensorimotor mechanism in fast and slow progression amyotrophic lateral sclerosis".HUMAN BRAIN MAPPING 43..5(2022):1710-1719
医学