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The effect of blood lipids on the comorbidity of multiple large arachnoid granulations

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机构: [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing 100053, China [2]Department of Neurology, Peking University First Hospital, Beijing 100034, China [3]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China [4]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI 48201, USA [5]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
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关键词: Arachnoid granulation Cerebral venous sinus stenosis Blood lipid Dyslipidemia High-resolution black blood magnetic resonance imaging

摘要:
Currently, studies on the formation mechanism for the enlargement of arachnoid granulation (AG) are lacking. The impact of dyslipidemia on the formation of multiple large arachnoid granulations (LAGs) was studied in this research.The study included patients diagnosed with cerebral venous sinus stenosis (CVSS) related to LAG. The number of LAGs was assessed via high-resolution black blood magnetic resonance imaging. The relationships between blood lipids and multiple LAGs were explored to evaluate the effects of dyslipidemia on the formation of multiple LAGs.A total of 163 participants with a diagnosis of LAG were included. The levels of total cholesterol (TC) (P = 0.004) and low-density lipoprotein cholesterol (LDL-c) (P = 0.01) in the multiple LAGs group were greater than those in the non-multiple LAGs group. Multivariate logistic regression analysis revealed that TC (odds ratio (OR), 2.19; 95% confidence interval (CI), 1.26-3.80; P = 0.006) and LDL-c (OR, 2.18; 95% CI, 1.16-4.07; P = 0.02) were independently associated with multiple LAGs.TC and LDL-c are independently related to multiple LAGs, indicating that dyslipidemia may be a potential cause of CVSS. Therefore, monitoring blood lipids may be necessary for patients with LAGs.© 2024. The Author(s).

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出版当年[2023]版:
大类 | 2 区 医学
小类 | 2 区 生化与分子生物学 3 区 营养学
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 生化与分子生物学 2 区 营养学
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出版当年[2022]版:
Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 NUTRITION & DIETETICS
最新[2023]版:
Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 NUTRITION & DIETETICS

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第一作者机构: [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing 100053, China [3]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China
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通讯机构: [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing 100053, China [3]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100053, China
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