Visual feedback training (VFT) plays an important role in the motor rehabilitation of patients with spinal cord injury (SCI). However, the neural mechanisms are unclear. We aimed to investigate the changes in dynamic functional network connectivity (FNC) related to visual networks (VN) in patients with SCI and to reveal the neural mechanism of VFT promoting motor function rehabilitation. Dynamic FNC and the sliding window method were performed in 18 complete SCI (CSCI), 16 patients with incomplete SCI (ISCI), and 42 healthy controls (HCs). Then, k-mean clustering was implemented to identify discrete FNC states, and temporal properties were computed. The correlations between these dynamic features and neurological parameters in all patients with SCI were calculated. The majority of aberrant FNC was manifested between VN and executive control network (ECN). In addition, compared with HCs, temporal metrics derived from state transition vectors were decreased in patients with CSCI including the mean dwell time and the fraction of time spent in state 3. Furthermore, the disrupted FNC between salience network and ECN in state 2 and the number of transitions were all positively correlated with neurological scores in patients with SCI. Our findings indicated that SCI could result in VN-related FNC alterations, revealing the possible mechanism for VFT in rehabilitation of patients with SCI and increasing the training efficacy and promoting rehabilitation for SCI.
基金:
National Natural Science Foundation of China [81871339, 81271556]; National Key Research and Development Program of China [2023YFF1204104]; Beijing Municipal Natural Science Foundation [7113155]; Science Foundation of Beijing Municipal Commission of Education [KM20 1210025013]
语种:
外文
WOS:
PubmedID:
中科院(CAS)分区:
出版当年[2023]版:
大类|2 区医学
小类|2 区临床神经病学2 区危重病医学2 区神经科学
最新[2023]版:
大类|2 区医学
小类|2 区临床神经病学2 区危重病医学2 区神经科学
JCR分区:
出版当年[2022]版:
Q2CLINICAL NEUROLOGYQ2CRITICAL CARE MEDICINEQ2NEUROSCIENCES
最新[2023]版:
Q1CLINICAL NEUROLOGYQ1CRITICAL CARE MEDICINEQ2NEUROSCIENCES
第一作者机构:[1]Capital Med Univ, Xuanwu Hosp, Dept Radiol & Nucl Med, Beijing, Peoples R China[2]Beijing Key Lab Magnet Resonance Imaging & Brain I, Beijing, Peoples R China
通讯作者:
通讯机构:[1]Capital Med Univ, Xuanwu Hosp, Dept Radiol & Nucl Med, Beijing, Peoples R China[2]Beijing Key Lab Magnet Resonance Imaging & Brain I, Beijing, Peoples R China[*1]Capital Med Univ, Xuanwu Hosp, Dept Radiol & Nucl Med, Beijing Key Lab Magnet Resonance Imaging & Brain I, 45 Chang Chun St, Beijing 100053, Peoples R China
推荐引用方式(GB/T 7714):
Xin Haotian,Yang Beining,Wang Yu,et al.Altered Dynamic Brain Functional Network Connectivity Related to Visual Network in Spinal Cord Injury[J].JOURNAL OF NEUROTRAUMA.2024,doi:10.1089/neu.2024.0318.
APA:
Xin, Haotian,Yang, Beining,Wang, Yu,Qi, Qunya,Wang, Ling...&Chen, Nan.(2024).Altered Dynamic Brain Functional Network Connectivity Related to Visual Network in Spinal Cord Injury.JOURNAL OF NEUROTRAUMA,,
MLA:
Xin, Haotian,et al."Altered Dynamic Brain Functional Network Connectivity Related to Visual Network in Spinal Cord Injury".JOURNAL OF NEUROTRAUMA .(2024)