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Altered Dynamic Brain Functional Network Connectivity Related to Visual Network in Spinal Cord Injury

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机构: [1]Capital Med Univ, Xuanwu Hosp, Dept Radiol & Nucl Med, Beijing, Peoples R China [2]Beijing Key Lab Magnet Resonance Imaging & Brain I, Beijing, Peoples R China [3]Capital Med Univ, Beijing Chaoyang Hosp, Dept Radiol, Beijing, Peoples R China [4]Capital Med Univ, Xuanwu Hosp, Dept Rehabil Med, Beijing, Peoples R China [5]Beijing Elect Power Hosp, Dept Radiol, Beijing, Peoples R China [6]Capital Med Univ, Beijing Friendship Hosp, Dept Radiol, Beijing, Peoples R China
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关键词: dynamic functional network connectivity resting-state functional magnetic resonance imaging spinal cord injury visual network

摘要:
Visual feedback training (VFT) plays an important role in the motor rehabilitation of patients with spinal cord injury (SCI). However, the neural mechanisms are unclear. We aimed to investigate the changes in dynamic functional network connectivity (FNC) related to visual networks (VN) in patients with SCI and to reveal the neural mechanism of VFT promoting motor function rehabilitation. Dynamic FNC and the sliding window method were performed in 18 complete SCI (CSCI), 16 patients with incomplete SCI (ISCI), and 42 healthy controls (HCs). Then, k-mean clustering was implemented to identify discrete FNC states, and temporal properties were computed. The correlations between these dynamic features and neurological parameters in all patients with SCI were calculated. The majority of aberrant FNC was manifested between VN and executive control network (ECN). In addition, compared with HCs, temporal metrics derived from state transition vectors were decreased in patients with CSCI including the mean dwell time and the fraction of time spent in state 3. Furthermore, the disrupted FNC between salience network and ECN in state 2 and the number of transitions were all positively correlated with neurological scores in patients with SCI. Our findings indicated that SCI could result in VN-related FNC alterations, revealing the possible mechanism for VFT in rehabilitation of patients with SCI and increasing the training efficacy and promoting rehabilitation for SCI.

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出版当年[2023]版:
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 危重病医学 2 区 神经科学
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 危重病医学 2 区 神经科学
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出版当年[2022]版:
Q2 CLINICAL NEUROLOGY Q2 CRITICAL CARE MEDICINE Q2 NEUROSCIENCES
最新[2023]版:
Q1 CLINICAL NEUROLOGY Q1 CRITICAL CARE MEDICINE Q2 NEUROSCIENCES

影响因子: 最新[2023版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

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第一作者机构: [1]Capital Med Univ, Xuanwu Hosp, Dept Radiol & Nucl Med, Beijing, Peoples R China [2]Beijing Key Lab Magnet Resonance Imaging & Brain I, Beijing, Peoples R China
通讯作者:
通讯机构: [1]Capital Med Univ, Xuanwu Hosp, Dept Radiol & Nucl Med, Beijing, Peoples R China [2]Beijing Key Lab Magnet Resonance Imaging & Brain I, Beijing, Peoples R China [*1]Capital Med Univ, Xuanwu Hosp, Dept Radiol & Nucl Med, Beijing Key Lab Magnet Resonance Imaging & Brain I, 45 Chang Chun St, Beijing 100053, Peoples R China
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