The asymmetric pattern of beta-amyloid plaque distribution across Alzheimer's disease clinical progression stages remains unclear. In this study, 66 participants with normal cognition, 59 with subjective cognitive decline, 12 with mild cognitive impairment, and 11 with Alzheimer's disease dementia were included in the Sino Longitudinal Study on Cognitive Decline (SILCODE) cohort. A regional asymmetry index, denoting the left-right asymmetry of beta-amyloid plaques, was derived for each region based on the Anatomical Automatic Labeling atlas. The level of beta-amyloid plaques in each region was compared among different clinical stages of Alzheimer's disease using the analysis of variance. An additional correlation analysis examined the relationship between each region of interest's cognitive performance scores and asymmetry index values. We found that beta-amyloid appears to be lateralized in different stages of Alzheimer's disease. In addition, there is a significant correlation between beta-amyloid asymmetry in various brain regions and cognition. The observed A beta lateralization could potentially be utilized as a neuroimaging biomarker throughout AD progression.