机构：[1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.神经科系统神经内科首都医科大学宣武医院[2]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China.[3]Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing, China.[4]Center of Alzheimer's Disease, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.[5]Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, China.[6]Department of Neurology, Gansu Provincial Hospital, Lanzhou City, Gansu Province, China.
Metabolic syndrome (MetS) was associated with an increased incidence of mild cognitive impairment (MCI) and progression to dementia.To study the associations between MetS indicators and cerebrospinal fluid (CSF) biomarkers in the participants.61 normal cognition, 66 mild MCI, and 135 dementia participants were included in our study, with the results of lumbar puncture and peripheral blood biochemistry. The CSF levels of amyloid-β (Aβ)42 protein, total tau protein, phosphorylated tau protein, and Aβ42/40 ratio, were selected as the biomarkers. The body mass index, the plasma high density lipoprotein cholesterol, uric acid, low density lipoprotein cholesterol, triglyceride, and homocysteine levels were selected as indicators of MetS. Linear regression model was used to analyze the correlation in all participants and different cognitive stages, controlling for age, gender, and APOE genotype.Our study showed that MetS indicators were associated with CSF biomarkers in participants after adjusting for possible confounding factors, including age, gender, and APOE genotype. The results of our grouping analysis further supported the potential association between plasma MetS indicators and CSF biomarkers in three group. We found that the dementia group showed the greatest correlation coefficient.The CSF pathological proteins concentrations were associated with MetS indicators, and the correlation coefficient were greater in the dementia stage. These findings suggest that regulating peripheral metabolism may affect the level of pathological proteins in the brain to improve cognitive impairment.
基金：
Key Project of the National Natural
Science Foundation of China (U20A20354); Beijing Brain
Initiative from Beijing Municipal Science & Technology
Commission (Z201100005520016, Z201100005520017);
STI2030-Major Projects (No.2021ZD0201802); the grant from
the Chinese Institutes for Medical Research (CX23YZ15); the
National Key Scientific Instrument and Equipment Development
Project (31627803); the Key Project of the National Natural
Science Foundation of China (81530036); the Youth Program of
National Natural Science Foundation of China (82101503);
Beijing Natural Science Foundation (L232136).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2024]版：
无
最新[2023]版：
大类|3 区医学
小类|3 区神经科学
第一作者：
第一作者机构：[1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.[2]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China.[3]Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing, China.[4]Center of Alzheimer's Disease, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.[5]Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, China.
通讯作者：
通讯机构：[1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.[2]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China.[3]Clinical Center for Neurodegenerative Disease and Memory Impairment, Capital Medical University, Beijing, China.[4]Center of Alzheimer's Disease, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.[5]Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing, China.
推荐引用方式(GB/T 7714)：
Ding Jiayi,Quan Meina,Zang Peixi,et al.Associations between serum metabolic syndrome indicators levels and cerebrospinal fluid pathological protein in dementia and pre-dementia patients[J].Journal Of Alzheimer's Disease : JAD.2025,13872877251318298.doi:10.1177/13872877251318298.
APA：
Ding Jiayi,Quan Meina,Zang Peixi&Jia Jianping.(2025).Associations between serum metabolic syndrome indicators levels and cerebrospinal fluid pathological protein in dementia and pre-dementia patients.Journal Of Alzheimer's Disease : JAD,,
MLA：
Ding Jiayi,et al."Associations between serum metabolic syndrome indicators levels and cerebrospinal fluid pathological protein in dementia and pre-dementia patients".Journal Of Alzheimer's Disease : JAD .(2025):13872877251318298
