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The Role of TREM2 in Myelin Sheath Dynamics: A Comprehensive Perspective from Physiology to Pathology

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Que Xinwei[1,2,3] * ; Zhang Tongtong[1,2] ; Liu Xueyu[1,2] ; Yin Yunsi[1,2] ; Xia Xinyi[1,2] ; Gong Ping[3] ; Song Weiyi[1,2,3] ; Qin Qi[1,2] ; Xu Zhi-Qing David[3] ; Tang Yi[1,2] ;
机构： [1]Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, 100053, China [2]Neurodegenerative Laboratory of Ministry of Education of the People's Republic of China, Beijing, 100053, China [3]Departments of Neurobiology and Pathology, Capital Medical University, 100069 Beijing, China.
出处：
DOI： 10.1016/j.pneurobio.2025.102732
ISSN：

关键词： TREM2 Myelin Demyelination Microglia

摘要：
Demyelinating disorders, characterizing by the loss of myelin integrity, present significant challenges due to their impact on neurological function and lack of effective treatments. Understanding the mechanisms underlying myelin damage is crucial for developing therapeutic strategies. Triggering receptor expressed on myeloid cells 2 (TREM2), a pivotal immune receptor predominantly found on microglial cells, plays essential roles in phagocytosis and lipid metabolism, vital processes in neuroinflammation and immune regulation. Emerging evidence indicates a close relationship between TREM2 and various aspects of myelin sheath dynamics, including maintenance, response to damage, and regeneration. This review provides a comprehensive discussion of TREM2's influence on myelin physiology and pathology, highlighting its therapeutic potential and putative mechanisms in the progression of demyelinating disorders.Copyright © 2025. Published by Elsevier Ltd.

基金：
This work was supported by the National Key Research and Development Program of China (2022YFC3602600), National Natural Science Foundation of China (82220108009), Beijing Outstanding Young Scientist Program (JWZQ20240101023), STI2030-Major Projects (2021ZD0201801), National Natural Science Foundation of China (82201568), Capital’s Funds for Health Improvement and Research (2024-2-1031), Beijing Nova Program (20240484566) and the R&D Program of Beijing Municipal Education Commission (KZ202110025041).
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 2 区 医学
小类 | 2 区 神经科学
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 神经科学
JCR分区：
出版当年[2023]版：
Q1 NEUROSCIENCES
最新[2023]版：
Q1 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

第一作者：
第一作者机构： [1]Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, 100053, China [2]Neurodegenerative Laboratory of Ministry of Education of the People's Republic of China, Beijing, 100053, China [3]Departments of Neurobiology and Pathology, Capital Medical University, 100069 Beijing, China.
通讯作者：
通讯机构： [1]Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, 100053, China [2]Neurodegenerative Laboratory of Ministry of Education of the People's Republic of China, Beijing, 100053, China
推荐引用方式(GB/T 7714)：
Que Xinwei,Zhang Tongtong,Liu Xueyu,et al.The Role of TREM2 in Myelin Sheath Dynamics: A Comprehensive Perspective from Physiology to Pathology[J].Progress In Neurobiology.2025,247:102732.doi:10.1016/j.pneurobio.2025.102732.
APA：
Que Xinwei,Zhang Tongtong,Liu Xueyu,Yin Yunsi,Xia Xinyi...&Tang Yi.(2025).The Role of TREM2 in Myelin Sheath Dynamics: A Comprehensive Perspective from Physiology to Pathology.Progress In Neurobiology,247,
MLA：
Que Xinwei,et al."The Role of TREM2 in Myelin Sheath Dynamics: A Comprehensive Perspective from Physiology to Pathology".Progress In Neurobiology 247.(2025):102732

相关文献

[1]TREM2, Microglia, and Alzheimer's Disease. [2]Icariin enhances remyelination process after acute demyelination induced by cuprizone exposure [3]TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology [4]Icariin ameliorates the cuprizone-induced acute brain demyelination and modulates the number of oligodendrocytes, microglia and astrocytes in the brain of C57BL/6J mice. [5]The clinical features of combined central and peripheral demyelination and antibodies against the node of Ranvier. [6]What do the conflicting findings in the trem2 transgenetic mouse model tell us? A systematic review of the role of TREM2 in Alzheimer's disease [7]两种髓鞘染色方法在Cuprizone诱导脱髓鞘小鼠模型中的比较 [8]The clinical features of combined central and peripheral demyelination and antibodies against the node of Ranvier. [9]The Specific Mechanism of TREM2 Regulation of Synaptic Clearance in Alzheimer's Disease [10]The Clinical Features of Combined Central and Peripheral Demyelination

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