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Icariin ameliorates the cuprizone-induced acute brain demyelination and modulates the number of oligodendrocytes, microglia and astrocytes in the brain of C57BL/6J mice.

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Cong Hengri[1] * ; Liang Mengru[2] * ; Wang Yupeng[1] ; Chang Haoxiao[1,2] ; Du Li[1] ; Zhang Xinghu[1] ; Yin Linlin[1,2,*1] ;
机构： [1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100160, China [2]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing Institute of Brain Disorders, No.45 Changchun Street, Xicheng District, Beijing, 100053, China
出处：
DOI： 10.1016/j.brainresbull.2021.07.010
ISSN：

关键词： Icariin Cuprizone Demyelination Oligodendrocytes Microglia

摘要：
This study aimed at testing the hypothesis that treatment with icariin (ICA, a type of flavonoid) could mitigate the cuprizone (CPZ)-induced acute demyelination in the brain of mice and the potential mechanisms. Female C57BL/6J mice were fed continually with regular rodent chow or the chow supplemented with CPZ (0.2 % w/w) for six weeks to induce acute demyelination. The CPZ-fed mice were treated with vehicle or ICA at 12.5 or 25 mg/kg beginning at three weeks post CPZ feeding daily for three weeks. Their brain tissue sections were stained with oil red O, luxol-fast blue (LFB) and immunohistochemistry to characterize the levels of brain demyelination, myelin basic protein (MBP) and brain-derived neurotrophic factor (BDNF) and the numbers of oligodendrocytes (Ols), oligodendrocyte progenitor cells (OPCs), microglia and astrocytes in mice. Compared with the healthy controls, CPZ feeding caused the brain demyelination by increasing NG2+ OPCs, but decreased oil red O and LFB staining, MBP level and GST-pi+ Ols in the brain corpus callosum region of mice. Furthermore, CPZ feeding decreased the number of BDNF+ cells in the brain cortex and hippocampus regions, but increased microglia in the brain corpus callosum, cortex and caudate putamen, and astrocytes in the corpus callosum regions of mice. Treatment with ICA significantly mitigated or abrogated the toxic demyelination of CPZ by preserving MBP and BDNF proteins and modulating the numbers of Ols, OPCs, microglia and astrocytes in the brain of mice. ICA treatment significantly ameliorated the CPZ-mediated demyelination and modulated the number of Ols, microglia and astrocytes in the brain of mice.Copyright © 2021 Elsevier Inc. All rights reserved.

基金：
Beijing Natural Science Foundation (No. 7212030, 7212029), the National Key Research and Development Program of China (No. 2019YFC0121202), Beijing Nova Program (No. Z12111000250000), and Capital Medical Development Special Program (No. 2011-1001-06).
语种：
外文
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WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 3 区 医学
小类 | 3 区 神经科学
最新[2023]版：
大类 | 3 区 医学
小类 | 3 区 神经科学
JCR分区：
出版当年[2019]版：
Q2 NEUROSCIENCES
最新[2023]版：
Q2 NEUROSCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100160, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100160, China [2]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing Institute of Brain Disorders, No.45 Changchun Street, Xicheng District, Beijing, 100053, China [*1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100160, China
推荐引用方式(GB/T 7714)：
Cong Hengri,Liang Mengru,Wang Yupeng,et al.Icariin ameliorates the cuprizone-induced acute brain demyelination and modulates the number of oligodendrocytes, microglia and astrocytes in the brain of C57BL/6J mice.[J].BRAIN RESEARCH BULLETIN.2021,175:37-47.doi:10.1016/j.brainresbull.2021.07.010.
APA：
Cong Hengri,Liang Mengru,Wang Yupeng,Chang Haoxiao,Du Li...&Yin Linlin.(2021).Icariin ameliorates the cuprizone-induced acute brain demyelination and modulates the number of oligodendrocytes, microglia and astrocytes in the brain of C57BL/6J mice..BRAIN RESEARCH BULLETIN,175,
MLA：
Cong Hengri,et al."Icariin ameliorates the cuprizone-induced acute brain demyelination and modulates the number of oligodendrocytes, microglia and astrocytes in the brain of C57BL/6J mice.".BRAIN RESEARCH BULLETIN 175.(2021):37-47

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