机构：[1]Department of Neurology and Department of Psychiatry, Wuxi Branch of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Wuxi, Jiangsu, China[2]Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China[3]Alzheimer’s Disease and Related Disorders Center, Shanghai Jiao Tong University, Shanghai, China[4]Department of Psychiatry, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China中山大学附属第三医院[5]Institute of Psychology, Chinese Academy of Sciences, Beijing, China[6]Guangzhou Brain Hospital, Guangzhou, Guangdong, China[7]Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China[8]Anding Hospital, Capital Medical University, Beijing, China[9]Institute of Mental Health, Peking University, Beijing, China[10]Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院[11]The First Affiliated Hospital of the China Medical University, Shenyang, Liaoning, China[12]The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China[13]The Third People’s Hospital of Ji’an City, Ji’an, Jiangxi, China[14]The Fourth People’s Hospital of Hefei City, Hefei, Anhui, China[15]East China Normal University, Shanghai, China[16]Tongji Hospital, Tongji University, Shanghai, China[17]Department of Neurosurgery, Clinical Neuroscience Center Comprehensive Epilepsy Unit, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[18]Ruijin Hospital Luwan Branch, Clinical Neuroscience Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China[19]Shanghai Research Center for Brain Science and Brain-Inspired Technology, Shanghai, China[20]Department of Psychiatry and Affective Disorders Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Background As the population in China rapidly ages, the prevalence of mild cognitive impairment (MCI) is increasing considerably. However, the causes of MCI vary. The continued lack of understanding of the various subtypes of MCI impedes the implementation of effective measures to reduce the risk of advancing to more severe cognitive diseases.Aims To estimate the prevalence and incidence rates of two MCI subtypes-amnestic MCI (aMCI) and vascular cognitive impairment without dementia (VCIND)-and to determine modifiable factors for them among older individuals in a multiregional Chinese cohort.Method This 1-year longitudinal study surveyed a random sample of participants aged >= 60 years from a large, community-dwelling cohort in China. Baseline lifestyle data were self-reported, while vascular and comorbid conditions were obtained from medical records and physical examinations. In total, 3514 and 2051 individuals completed the baseline and 1-year follow-up assessments, respectively. Logistic and linear regression analyses were used to identify the modifiable factors for MCI subtypes and predictors of cognitive decline, respectively.Results Among our participants, aMCI and VCIND demonstrated prevalence of 14.83% and 2.71%, respectively, and annual incidence (per 1000 person-years) of 69.6 and 10.6, respectively. The risk factor for aMCI was age, whereas its protective factors were high education level, tea consumption and physical activity. Moreover, VCIND risk factors were age, hypertension and depression. The presence of endocrine disease, cerebral trauma or hypertension was associated with a faster decline in cognition over 1 year.Conclusions MCI is a serious health problem in China that will only worsen as the population ages if no widespread interventions are implemented. Preventive strategies that promote brain activity and support healthy lifestyle choices are required. We identified modifiable factors for MCI in older individuals. The easy-to-adopt solutions such as tea consumption and physical activity can aid in preventing MCI.Trial registration number NCT03672448.
基金：
Major Project of Wuxi Municipal Health Commission [Z202406]; Jiangsu Commission of Health Program [M2024010]; National Key Research and Development Program [2022YFC3600600]; China Ministry of Science and Technology grants [2009BAI77B03]; Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support [20172029]; Innovative Research Team of High-level Local Universities in Shanghai [ZDCX20211201]
第一作者机构：[1]Department of Neurology and Department of Psychiatry, Wuxi Branch of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Wuxi, Jiangsu, China[2]Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China[3]Alzheimer’s Disease and Related Disorders Center, Shanghai Jiao Tong University, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology and Department of Psychiatry, Wuxi Branch of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Wuxi, Jiangsu, China[2]Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China[3]Alzheimer’s Disease and Related Disorders Center, Shanghai Jiao Tong University, Shanghai, China
推荐引用方式(GB/T 7714)：
Wang Tao,He Haining,Shi Yanchen,et al.Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China[J].GENERAL PSYCHIATRY.2025,38(2):doi:10.1136/gpsych-2024-101736.
APA：
Wang, Tao,He, Haining,Shi, Yanchen,Su, Ning,Zhu, Minjie...&Xiao, Shifu.(2025).Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China.GENERAL PSYCHIATRY,38,(2)
MLA：
Wang, Tao,et al."Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China".GENERAL PSYCHIATRY 38..2(2025)
