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Mapping human brain topography to heart rhythms: an SEEG study

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Pubmed体系：
作者：
Wang Xiaopeng[1,2,3,4] * ; Yang Haoxun[1,2,3] * ; Cheng Yueyang[1,2,3] * ; Liu Shujia[5] ; Jin Guangyuan[1,2,3,6] ; Qiao Zichen[1,2,3] ; Qi Lei[7] ; Wang Siyi[1,2,3] ; Ge Junliang[1,2,3] ; Hu Dongmei[1,2,3] ; Tang Hai[4] ; Gao Runshi[3,8] ; Xu Cuiping[3,8] ; Zhang Xiaohua[3,8] ; Wang Di[9] ; Xue Xiangyu[9] ; Dai Anqi[9] ; Zhao Wenbo[1,3] ; Yu Tao[3,8] ; Wang Yuping[1,2] ; Si Bailu[6,10] ; Zhao Guoguang[3,8] ; Ren Liankun[1,2,3,11] ;
机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [2]Clinical Research Center of Epilepsy, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [3]National Center for Neurological Disorders, Beijing 100053, China. [4]Department of Neurology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221006, China. [5]School of Systems Science, Beijing Normal University, Beijing 100875, China. [6]Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. [7]China Rehabilitation Research Centre, CRRC (Beijing Boai Hospital), Beijing 100068, China. [8]Department of neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [9]School of Engineering Medicine, Beihang University, Beijing, 100191, China. [10]Chinese Institute for Brain Research, Beijing 102206, China. [11]Jinan Hospital of Xuanwu Hospital, Shandong First Medical University, 250102, Jinan, China.
出处：
DOI： 10.1093/cvr/cvaf099
ISSN：

关键词： Heart–brain interaction Heartbeat-evoked potentials Stereo-electroencephalography

摘要：
The interplay between the heart and brain has been a subject of interest for centuries, as dysfunction in this interaction is implicated in various cardiovascular diseases and neurological disorders. Despite this advancement, there is currently a limited understanding of the mechanisms that the human brain communicates with heart rhythms. Here, we aim to characterize the human brain processing of heart rhythms and map human brain topography to heart rhythms.We investigated how the human brain processes heart rhythms in a cohort of 54 drug-resistant epilepsy patients who simultaneously recorded electrocardiography and stereoelectroencephalography (SEEG) during pre-surgical evaluation. Intracranial heartbeat-evoked potentials (HEPs) derived from averaging brain responses time-locked to R peaks of heartbeats in consecutive resting-state SEEG epochs, were characterized in terms of their morphology and spatiotemporal distribution across the brain. The analysis revealed a complex brain topography to heart rhythms that includes the anticipated bilateral thalamus, insula, amygdala, and anterior cingulate cortex, while also extending to the dorsolateral prefrontal cortex, supramarginal gyrus, and superior temporal gyrus. Employing an eigen microstates approach, we disentangled two prominent components of the HEPs network in the time window from 100 to 400 ms post R-peak, reflecting early (100-250 ms) and delayed (250-400 ms) processing pathways. Furthermore, we mapped human brain neurotransmitter receptor signatures onto the HEPs topography, providing the first evidence that serotonin receptor 5HT2a serves as a dominant signature of this organization at the cortical level. Additionally, brain regions exhibiting stronger HEPs showed more pronounced heart rate changes following direct electrical stimulation (DES) via SEEG.We generated a spatiotemporal dynamic map of HEPs across cortical and subcortical regions. Our characterization of HEPs revealed various dominant components and established a direct association between its topographic organization and distribution of neurotransmitter receptors. This study provides a foundational framework for understanding the brain processing of heart signals and paves the way for novel therapeutic interventions and cardiovascular diseases.© The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

基金：
This work was supported by Beijing Hospitals Authority Clinical Medicine Development of special funding support (ZLRK202321 to L.K.R.); National Key R&D Programmes of China (2022YFC2503805, 2024YFA1306903 to L.K.R.); National Natural Science Foundation of China (82371457 to L.K.R.); Beijing Research Ward Excellence Program (BRWEP2024 W022010200 to L.K.R.) and the Project Funded by Priority Academic Program Development of Jiangsu Higher Education Institutions (XZSYSKF2021024 to X.P.W).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类 | 1 区 医学
小类 | 2 区 心脏和心血管系统
最新[2025]版：
大类 | 1 区 医学
小类 | 2 区 心脏和心血管系统
第一作者：
第一作者机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [2]Clinical Research Center of Epilepsy, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [3]National Center for Neurological Disorders, Beijing 100053, China. [4]Department of Neurology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221006, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [2]Clinical Research Center of Epilepsy, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [3]National Center for Neurological Disorders, Beijing 100053, China. [6]Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. [8]Department of neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. [10]Chinese Institute for Brain Research, Beijing 102206, China. [11]Jinan Hospital of Xuanwu Hospital, Shandong First Medical University, 250102, Jinan, China.
推荐引用方式(GB/T 7714)：
Wang Xiaopeng,Yang Haoxun,Cheng Yueyang,et al.Mapping human brain topography to heart rhythms: an SEEG study[J].Cardiovascular Research.2025,doi:10.1093/cvr/cvaf099.
APA：
Wang Xiaopeng,Yang Haoxun,Cheng Yueyang,Liu Shujia,Jin Guangyuan...&Ren Liankun.(2025).Mapping human brain topography to heart rhythms: an SEEG study.Cardiovascular Research,,
MLA：
Wang Xiaopeng,et al."Mapping human brain topography to heart rhythms: an SEEG study".Cardiovascular Research .(2025)

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