机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China重点科室诊疗科室神经外科神经外科首都医科大学附属天坛医院[2]Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China研究所北京市神经外科研究所首都医科大学附属天坛医院[3]Beijing Key Laboratory of Neurostimulation, Beijing, China
Objectives Deep brain stimulation (DBS) and stereo-electroencephalography (SEEG) electrode implantation are the most important and frequent manipulations in nonhuman primates (NHP) neuromodulation research. However, traditional methods tend to be arduous and inaccurate. Materials and Methods Twelve adult male rhesus monkeys were selected for the study, with six subthalamic nucleus (STN) DBS, six anterior nucleus of the thalamus (ANT) DBS and six hippocampus-SEEG (Hippo-SEEG) electrodes implantation. Mean Euclidean errors of entrance and the target were calculated by postoperative image fusion, and the correlation between entrance and target error, as well as the differences among the various manipulations, were analyzed. The accuracy of target was further confirmed by gross anatomy examination. Moreover, the time consumption was recorded. Results The mean (+/- SD) Euclidean errors of the target point and entry point of the three manipulations were STN-DBS: 1.05 +/- 0.54 mm and 0.52 +/- 0.17 mm; ANT-DBS: 1.12 +/- 0.74 mm and 0.58 +/- 0.24 mm; and Hippo-SEEG: 2.68 +/- 1.03 mm and 1.47 +/- 0.63 mm. Significant differences were observed in both target and entry point errors between the DBS and Hippo-SEEG groups, with superior accuracy in the DBS group. The entrance errors had a significantly positive correlation with the target errors in the STN-DBS and Hippo-SEEG groups. Moreover, the time consumption in robotic surgery was much shorter than that in the traditional method, without any severe complications. Conclusion The application of robot-assisted lead implantation in NHP neuromodulation research is feasible, accurate, safe, and efficient, and can prospectively be beneficial to neurological studies.
基金：
National Nature Science Foundation of ChinaNational Natural Science Foundation of China [61761166004, 81701268]; Scientific Research Common Program of the Beijing Municipal Commission of Education [KZ201510025029]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018 T110120]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|3 区临床神经病学3 区医学：研究与实验
最新[2023]版：
大类|3 区医学
小类|3 区临床神经病学3 区医学：研究与实验
JCR分区：
出版当年[2017]版：
Q2CLINICAL NEUROLOGYQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q2CLINICAL NEUROLOGYQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[2]Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China[3]Beijing Key Laboratory of Neurostimulation, Beijing, China[*1]Functional and Stereotactic Laboratory, Beijing Neurosurgical Institute, South Four Ring West Road No. 119, B district, Fengtai Dist, Beijing, 100070, China[*2]Functional and Stereotactic Laboratory, Beijing Neurosurgical Institute, South Four Ring West Road No. 119, B district, Fengtai Dist, Beijing, 100070, China.
推荐引用方式(GB/T 7714)：
Zhu Guan-Yu,Chen Ying-Chuan,Du Ting-Ting,et al.The Accuracy and Feasibility of Robotic Assisted Lead Implantation in Nonhuman Primates[J].NEUROMODULATION.2019,22(4):441-450.doi:10.1111/ner.12951.
APA：
Zhu, Guan-Yu,Chen, Ying-Chuan,Du, Ting-Ting,Liu, De-Feng,Zhang, Xin...&Zhang, Jian-Guo.(2019).The Accuracy and Feasibility of Robotic Assisted Lead Implantation in Nonhuman Primates.NEUROMODULATION,22,(4)
MLA：
Zhu, Guan-Yu,et al."The Accuracy and Feasibility of Robotic Assisted Lead Implantation in Nonhuman Primates".NEUROMODULATION 22..4(2019):441-450
