机构：[1]Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, China.血管超声科首都医科大学宣武医院[2]Department of Neurology, First Hospital of Jilin University, China.[3]Department of Ultrasonography, The First Affiliated Hospital of Soochow University, China.[4]Department of Ultrasonography, Lanzhou University Second Hospital, China.[5]Department of Ultrasonography, Tianjin Huanhu Hospital, China.[6]Department of Ultrasonography, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, China.[7]Department of Ultrasonography, The First Affiliated Hospital of Shanxi Medical University, China.[8]Department of Neurology, Luoyang Central Hospital Affiliated to Zhengzhou University, China.[9]Department of Ultrasonography, Liaocheng Brain Hospital, China.[10]Department of Ultrasonography, First Affiliated Hospital of Harbin Medical University, China.[11]Department of Ultrasonography, Anhui Provincial Hospital, China.[12]Department of Ultrasonography, First Hospital of China Medical University, China.[13]Department of Neurology, Baotou City Central Hospital, China.[14]Department of Ultrasonography, Fujian Provincial Hospital, China.[15]Department of Ultrasonography, Mianyang Central Hospital, China.[16]Department of Ultrasonography, First Affiliated Hospital of Xinjiang Medical University, China.[17]Department of Ultrasonography, Guangdong Provincial Hospital of Traditional Chinese Medicine, China.[18]Department of Neurology, The Second Affiliated Hospital of Kunming Medical University, China.[19]Department of Ultrasonography, Zhuhai People's Hospital, China.[20]Department of Ultrasonography, Brain Hospital of Hunan Province, China.
The aim of this multicenter study was to demonstrate the distribution pattern of atherosclerotic stenosis and its trend with aging between extracranial and intracranial arteries and its distribution between the anterior and posterior circulations in Chinese patients hospitalized with ischemic stroke. In addition, the risk factors for the distribution pattern were illustrated. From June 2015 to May 2016, 9,346 patients with ischemic stroke from 20 hospitals were enrolled. Carotid artery ultrasonography and transcranial color-coded sonography/transcranial Doppler were used to evaluate the extracranial and intracranial arteries. The distribution pattern of atherosclerotic stenosis and its trend with aging were analyzed. Logistic regression was used to analyze the risk factors for the distribution pattern. Among the 9,346 patients, 2,882 patients (30.8%) had at least one artery with a degree of stenosis >= 50%. Among patients with arterial stenosis, the proportion of patients with intracranial artery stenosis was higher than those with extracranial artery stenosis (52.6% vs. 27.6%), and the proportion of anterior circulation artery stenosis was higher than that in the posterior circulation (52.2% vs. 26.2%). With aging, the proportion of intracranial artery stenosis alone decreased; at the same time, the proportion of extracranial artery stenosis and extracranial plus intracranial artery stenosis increased (trend chi(2)=6.698, P=0.001). Hypertension (OR 1.416, P=0.008) and family history of stroke (OR 1.479, P=0.014) were risk factors for intracranial artery stenosis. Male, aging, and smoking were factors more related to extracranial artery stenosis. Aging (OR 1.022, P<0.001) and hypertension (OR 1.392, P=0.019) were related to posterior circulation artery stenosis. Intracranial arteries and anterior circulation arteries were susceptible to stenosis in Chinese patients with ischemic stroke. However, the distribution pattern of atherosclerotic stenosis was dynamic and varied with aging. Aging and different risk factors contribute to this distribution pattern.
基金：
National Health and Family Planning Commission Stroke Prevention Engineering Committee
第一作者机构：[1]Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, China.
通讯作者：
通讯机构：[1]Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, China.
推荐引用方式(GB/T 7714)：
Yang Hua,Lingyun Jia,Yingqi Xing,et al.Distribution Pattern of Atherosclerotic Stenosis in Chinese Patients with Stroke: A Multicenter Registry Study[J].AGING AND DISEASE.2019,10(1):62-70.doi:10.14336/AD.2018.0602.
APA：
Yang Hua,Lingyun Jia,Yingqi Xing,Pinjing Hui,Xuan Meng...&Xiaoyu Cai.(2019).Distribution Pattern of Atherosclerotic Stenosis in Chinese Patients with Stroke: A Multicenter Registry Study.AGING AND DISEASE,10,(1)
MLA：
Yang Hua,et al."Distribution Pattern of Atherosclerotic Stenosis in Chinese Patients with Stroke: A Multicenter Registry Study".AGING AND DISEASE 10..1(2019):62-70
