机构：[1]Division of Neonatology, Children’s Hospital of Soochow University, Suzhou 215025, China.[2]Department of Endocrinology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China.[3]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou 215004, China.[4]Institute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou 215025, China
BackgroundTo compare neurocognitive functioning of Type 1 diabetic mellitus (T1DM) and healthy adults, and explore risk factors of cognitive dysfunction of T1DM patients, especially the association between cognitive impairment and diabetic peripheral neuropathy (DPN).MethodsSeventy T1DM (age: 32.179.57yr., duration: 8.997.02yr) patients and 48 healthy volunteers were included. All subjects received evaluation of MMSE and MoCA scales. Cognitive function of T1DM patients was evaluated in different cognitive domains. Risk factors affecting cognitive function were further explored.Results Three patients with educational level6-year were excluded from final analysis. Scores of both MMSE (28.4 +/- 1.7 vs. 29.1 +/- 1.0, P=0.005) and MoCA scales (25.9 +/- 2.7 vs.27.1 +/- 2.4, P=0.017) in T1DM group were lower than that in control group. For MMSE scale, scores of orientation (9.60 +/- 0.79 vs.9.87 +/- 0.39, P<0.001) and language function (8.56 +/- 0.65 vs.8.83 +/- 0.38, P<0.001) in T1DM groups were lower than that in control group. For MoCA scale, scores of attention and concentration (2.30 +/- 0.74 vs.2.57 +/- 0.58, P<0.001), visuospatial/executive function (4.32 +/- 0.91 vs.4.64 +/- 0.63, P<0.001), memory (2.96 +/- 1.50 vs.3.66 +/- 1.28, P<0.001), language function (5.71 +/- 0.69 vs.5.87 +/- 0.39, P=0.007), and abstraction (1.55 +/- 0.68 vs.1.82 +/- 0.42, P<0.001) were lower in T1DM group than that in control group. Logistic regression showed age, fasting C peptide, educational level and nerve conduction velocity (NCV) were associated with cognitive dysfunction diagnosed by MoCA scores for the patients with type 1 diabetes.ConclusionsT1DM adults had mild to moderate cognitive impairment, mainly presenting as dysfunctions of attention and concentration, visuospatial/executive, language, and abstraction. In addition to age, fasting C peptide level, and educational level, DPN, as a diabetic complication, was identified to be associated with cognitive impairments.
基金：
National Natural Science Foundation of China [81501291, 81471195, 81871193]; preponderant clinic discipline group project funding of the Second Affiliated Hospital of Soochow University [XKQ2015002]
第一作者机构：[1]Division of Neonatology, Children’s Hospital of Soochow University, Suzhou 215025, China.
共同第一作者：
通讯作者：
通讯机构：[3]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou 215004, China.
推荐引用方式(GB/T 7714)：
Ding Xin,Fang Chen,Li Xiang,et al.Type 1 diabetes-associated cognitive impairment and diabetic peripheral neuropathy in Chinese adults: results from a prospective cross-sectional study[J].BMC ENDOCRINE DISORDERS.2019,19(1):34.doi:10.1186/s12902-019-0359-2.
APA：
Ding, Xin,Fang, Chen,Li, Xiang,Cao, Yong-Jun,Zhang, Qi-Lin...&Zhang, Xia.(2019).Type 1 diabetes-associated cognitive impairment and diabetic peripheral neuropathy in Chinese adults: results from a prospective cross-sectional study.BMC ENDOCRINE DISORDERS,19,(1)
MLA：
Ding, Xin,et al."Type 1 diabetes-associated cognitive impairment and diabetic peripheral neuropathy in Chinese adults: results from a prospective cross-sectional study".BMC ENDOCRINE DISORDERS 19..1(2019):34
