Objective: Gallstone formation is a pathological process of mineralization in the human body. Determination of the morphology and ultrastructure of gallstones holds the key to understanding the pathophysiology of gallbladder disease. Synchrotron radiation phase-contrast Xray microtomography is a novel technology, which is designed for comprehensive analysis of gallstone ultrastructure. Materials and Methods: Nine human gallstones were obtained from the Department of Pathology, Qingpu branch of Zhongshan Hospital Affiliated to Fudan University (China), and scanned by synchrotron radiation mu CT (SR mu CT). The imaging data generated by SR mu CT scan were analyzed. Results: The three-dimensional ultrastructure of human gallstones corresponding to their cholesterol and bile pigment composition was determined. Conclusions: The ultrastructure of gallstones exhibits considerable diversity and complexity. The synchrotron radiation phase-contrast X-ray microtomography is a valuable tool for in-depth study of human gallstones.
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|4 区医学
小类|4 区生化研究方法4 区应用化学4 区药学
最新[2023]版：
大类|4 区医学
小类|4 区生化研究方法4 区应用化学4 区药学
JCR分区：
出版当年[2017]版：
Q3CHEMISTRY, APPLIEDQ4BIOCHEMICAL RESEARCH METHODSQ4PHARMACOLOGY & PHARMACY
最新[2023]版：
Q3PHARMACOLOGY & PHARMACYQ3CHEMISTRY, APPLIEDQ4BIOCHEMICAL RESEARCH METHODS
第一作者机构：[1]Soochow Univ, Dept Gen Surg, Affiliated Hosp 2, 1055 Sanxiang Rd, Suzhou 215004, Peoples R China;[2]Qingdao Univ, Yantai Yuhuangding Hosp, Dept Cent Lab, Yantai, Shandong, Peoples R China;
推荐引用方式(GB/T 7714)：
Chen W,Liu R,Tao S,et al.Ultrastructural Analysis of Human Gallstones using Synchrotron Radiation mu CT[J].COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING.2019,22(1):doi:10.2174/1386207322666190222122007.
APA：
Chen W,Liu R,Tao S,Shen W,Zhou W...&Xing C.(2019).Ultrastructural Analysis of Human Gallstones using Synchrotron Radiation mu CT.COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,22,(1)
MLA：
Chen W,et al."Ultrastructural Analysis of Human Gallstones using Synchrotron Radiation mu CT".COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING 22..1(2019)
