机构：[1]Department of Immunology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.[2]Department of Clinical Laboratory, Suzhou No. 7 People’s Hospital, Suzhou, China.[3]Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, China.[4]Institute of Blood and Marrow Transplantation, Soochow University, Suzhou, China.[5]Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.[6]Comprehensive Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou, China.[7]Clinical Immunology Institute, The First Affiliated Hospital of Soochow University, Suzhou, China.[8]Jiangsu Key Laboratory of Clinical Immunology, Soochow University, Suzhou, China.[9]Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Interleukin-33 (IL-33) is a cytokine with pleiotropic functions in various diseases; however, its role in the antitumor immune response is still unclear. We found the expression of IL-33/ST2 in nonsmall cell lung tumor microenvironment. Furthermore, we found that IL-33 promoted effector functions of CD8(+) T cells that play a critical role in antitumor immune response. In addition, we found that IL-33 enhanced tumor vaccine effector functions in mice. Altogether, these findings suggest that IL-33, through facilitates CD8(+) T cells in microenvironment to provide a profound effect in antitumor immunotherapy.
基金：
This work was mainly supported by the National Natural
Science Foundation of China (grants 31670916 and
81273208 to Y.Z., 81402547 to Y.G.), Suzhou industrial
technology innovation special fund (SS201664 to Y.Z.).
第一作者机构：[1]Department of Immunology, School of Biology and Basic Medical Sciences, Soochow University, Suzhou, China.[2]Department of Clinical Laboratory, Suzhou No. 7 People’s Hospital, Suzhou, China.
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Immunology, School of Biology and Basic Medical Sciences Soochow University, 199 Renai Road, Suzhou 215123, China
推荐引用方式(GB/T 7714)：
Xiaochen Li ,Quansheng Lv ,Yuehua Feng ,et al.Interleukin-33, a Potential Cytokine Expressed in Tumor Microenvironment Involves in Antitumor Immunotherapy Through Facilitates CD8(+) T Cells[J].JOURNAL OF INTERFERON AND CYTOKINE RESEARCH.2018,38(11):491-499.doi:10.1089/jir.2018.0069.
APA：
Xiaochen Li,,Quansheng Lv,,Yuehua Feng,,Yanzheng Gu,,Rui Xia,...&Yibei Zhu.(2018).Interleukin-33, a Potential Cytokine Expressed in Tumor Microenvironment Involves in Antitumor Immunotherapy Through Facilitates CD8(+) T Cells.JOURNAL OF INTERFERON AND CYTOKINE RESEARCH,38,(11)
MLA：
Xiaochen Li,,et al."Interleukin-33, a Potential Cytokine Expressed in Tumor Microenvironment Involves in Antitumor Immunotherapy Through Facilitates CD8(+) T Cells".JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 38..11(2018):491-499
