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Mcl-1 regulates effector and memory CD8 T-cell differentiation during acute viral infection

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收录情况： ◇ SCIE

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机构： [1]Univ Wisconsin, Dept Pathobiol Sci, 2015 Linden Dr, Madison, WI 53706 USA; [2]Dartmouth Med Sch, Dept Pharmacol & Toxicol, Hanover, NH 03755 USA; [3]Beijing Childrens Hosp, Beijing Pediat Res Inst, Immunol Lab, Beijing 100045, Peoples R China; [4]Capital Med Univ, Beijing 100045, Peoples R China

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关键词： Myeloid cell leukemia 1 Lymphocytic choriomeningitis virus Effector Memory Central memory Effector memory Differentiation Apoptosis Mammalian target of rapamycin

摘要：

Mcl-1, an anti-apoptotic member of Bcl-2 family maintains cell viability during clonal expansion of CD8 T cells, but the cell intrinsic role of Mcl-1 in contraction of effectors or the number of memory CD8 T cells is unknown. Mcl-1 levels decline during the contraction phase but rebound to high levels in memory CD8 T cells. Therefore, by overexpressing Mcl-1 in CD8 T cells we asked whether limiting levels of Mcl-1 promote contraction of effectors and constrain CD8 T-cell memory. Mcl-1 overexpression failed to affect CD8 T-cell expansion, contraction or the magnitude of CD8 T-cell memory. Strikingly, high Mcl-1 levels enhanced mTOR phosphorylation and augmented the differentiation of terminal effector cells and effector memory CD8 T cells to the detriment of poly-cytokine-producing central memory CD8 T cells. Taken together, these findings provided unexpected insights into the role of Mcl-1 in the differentiation of effector and memory CD8 T cells. (C) 2016 Elsevier Inc. All rights reserved.

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中科院(CAS)分区：

出版当年[2015]版：

大类 | 3 区医学

小类 | 3 区病毒学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区病毒学

JCR分区：

出版当年[2014]版：

Q2 VIROLOGY

最新[2023]版：

Q3 VIROLOGY

影响因子： 2.8 最新[2023版] 2.7 最新五年平均 3.321 出版当年[2014版] 3.177 出版当年五年平均 3.278 出版前一年[2013版] 3.2 出版后一年[2015版]

第一作者：

第一作者机构： [1]Univ Wisconsin, Dept Pathobiol Sci, 2015 Linden Dr, Madison, WI 53706 USA;

通讯作者：

通讯机构： [1]Univ Wisconsin, Dept Pathobiol Sci, 2015 Linden Dr, Madison, WI 53706 USA;

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