机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China[2]Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China[3]Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China
Background: Sleep disturbance is one of the major non-motor symptoms which cause the disability of Parkinson's disease (PD) patients. Cystatin C (CysC) is a more sensitive biomarker than serum creatinine or estimated glomerular filtration rate. Previous studies have reported altered CysC levels in neurodegenerative disorders and sleep disorders. This study aimed to explore the correlations of serum CysC levels and objective sleep disturbances in early PD. Methods: We recruited 106 early PD patients and 146 age- and sex-matched controls. All participants underwent clinical investigation and video-polysomnography. Sleep parameters and serum levels of CysC were measured. Then, we.investigated the relationships between CysC and clinical variables and objective sleep disturbances in early PD patients. Results: The mean serum level of CysC was significantly higher in patients with early PD (1.03 +/- 0.19 mg/L) compared to controls (0.96 +/- 0.15 mg/L, P = 0.009). There were significantly positive correlations between serum CysC levels and age (r = 0.334, P < 0.001), gender (r = 0.264, P = 0.013), and creatinine levels (r = 0.302, P = 0.018) in early PD patients. Increased serum CysC levels in early PD patients were significantly associated with higher apnea and hypopnea index (AHI) (r = 0.231, P = 0.017), especially hypopnea index (r = 0.333, P < 0.001). In early PD patients, elevated serum CysC levels were positively correlated with oxygen desaturation index (r = 0.223, P = 0.021), percentage of time spent at oxygen saturation (SaO(2)) <90% (r = 0.644, P < 0.001), arousal with respiratory event during sleep (r = 0.247, P = 0.013). On the contrary, the elevated serum CysC levels were negatively correlated with mean and minimal SaO(2) (r = -0.323, -0.315, both P = 0.001) in PD patients. Conclusions: The level of serum CysC was higher in early PD patients. PD patients with elevated serum CysC levels had more respiratory events and more severe oxygen desaturation. Therefore, the serum CysC levels may predict the severities of sleep-disordered breathing problems in early PD patients.
基金：
This work was supported by grants from National Key R
and D Program of China (No. 2017YFC0909100); National
Natural Science Foundation of China (No. 91649114);
Jiangsu Provincial Medical Key Discipline Project (No.
ZDXKB2016022); Jiangsu Provincial social development
projects (No. BE2017653); Jiangsu Key Laboratory of
Neuropsychiatric Diseases (No. BM2013003); Suzhou
Clinical Research Center of Neurological Disease (No.
Szzx201503).
第一作者机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China
通讯作者：
通讯机构：[*1]Department of Neurology, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu 215004, China
推荐引用方式(GB/T 7714)：
Kang-Ping Xiong,Yong-Ping Dai,Jing Chen,et al.Increased Serum Cystatin C in Early Parkinson's Disease With Objective Sleep Disturbances[J].CHINESE MEDICAL JOURNAL.2018,131(8):907-911.doi:10.4103/0366-6999.229902.
APA：
Kang-Ping Xiong,Yong-Ping Dai,Jing Chen,Jin-Min Xu,Yi Wang...&Chun-Feng Liu.(2018).Increased Serum Cystatin C in Early Parkinson's Disease With Objective Sleep Disturbances.CHINESE MEDICAL JOURNAL,131,(8)
MLA：
Kang-Ping Xiong,et al."Increased Serum Cystatin C in Early Parkinson's Disease With Objective Sleep Disturbances".CHINESE MEDICAL JOURNAL 131..8(2018):907-911
