机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease,Suzhou, China[2]Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China[3]Institute of Neuroscience, Soochow University, Suzhou, China.
Objective:We investigated the relationship between serum cystatin C (CysC) levels and cognitive dysfunction and disease progression in patients with Parkinson disease.Background:Previous studies have reported altered CysC levels in neurodegenerative disorders, but only a few studies have explored the role of CysC and its relationship to cognitive dysfunction in Parkinson disease.Methods:We measured serum levels of CysC, creatinine, urea, and uric acid in 142 patients with Parkinson disease and 146 healthy controls. We assessed disease progression using the Hoehn and Yahr scale, and cognitive function using the Montreal Cognitive Assessment (Beijing version).Results:The patients with Parkinson disease had significantly higher CysC levels than the controls (P<0.001). CysC level correlated significantly with age (r=0.494, P<0.001), sex (r=0.150, P=0.011), and serum creatinine level (r=0.377, P<0.001), but not with levels of urea or uric acid (P>0.05). CysC level was a significant independent predictor of Parkinson disease (odds ratio=23.143, 95% confidence interval: 5.485-97.648, P<0.001) in multivariate logistic regression analysis. In the Parkinson disease group, a higher CysC level was associated with a more advanced Hoehn and Yahr stage (r=0.098, P<0.05) and a lower Montreal Cognitive Assessment score (r=-0.381, P=0.003).Conclusions:Serum CysC levels can predict disease severity and cognitive dysfunction in patients with Parkinson disease. The exact role of CysC remains to be determined.
基金：
Supported in part by grants from the National Natural Science Foundation
of China (81301011 to J.C.), Jiangsu Provincial Special Program
of Medical Science (BL2014042 to C.-F.L.), Suzhou Clinical
Key Disease Diagnosis and Treatment Technology Foundation
(LCZX201304 to C.-F.L.), Suzhou Clinical Research Center of
Neurological Disease (Szzx201503 to C.-F.L.), and the Priority
Academic Program Development of Jiangsu Higher Education
Institutions (C.-F.L.).
第一作者机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease,Suzhou, China
通讯作者：
通讯机构：[*1]Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou City, Jiangsu 215004, China
推荐引用方式(GB/T 7714)：
Wei-Dong Hu,Jing Chen,Cheng-Jie Mao,et al.Elevated Cystatin C Levels Are Associated with Cognitive Impairment and Progression of Parkinson Disease[J].COGNITIVE AND BEHAVIORAL NEUROLOGY.2016,29(3):144-9.doi:10.1097/WNN.0000000000000100.
APA：
Wei-Dong Hu,Jing Chen,Cheng-Jie Mao,Ping Feng,Ya-Ping Yang...&Chun-Feng Liu.(2016).Elevated Cystatin C Levels Are Associated with Cognitive Impairment and Progression of Parkinson Disease.COGNITIVE AND BEHAVIORAL NEUROLOGY,29,(3)
MLA：
Wei-Dong Hu,et al."Elevated Cystatin C Levels Are Associated with Cognitive Impairment and Progression of Parkinson Disease".COGNITIVE AND BEHAVIORAL NEUROLOGY 29..3(2016):144-9
