机构：[1]Department of Neurology, Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China,[2]Department of Neurology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China,[3]School of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China,[4]Department of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China,[5]Zhejiang Provincial Top Key Discipline in Surgery, Wenzhou Key Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China
Multiple system atrophy with predominant parkinsonism (MSA-P) is a degenerative disorder that presents with autonomic dysfunction, atypical parkinsonism, and ataxia. Parkinson's disease (PD) is an age-related neurological disorder of the central nervous system. Differentiation between MSA-P and PD is important because treatments, complications, and prognoses differ. The bulbocavernosus reflex (BCR) tests the afferent and efferent signals of the pudendal nerve as well as the sacral cord. In this study, we investigated differences in BCR parameters between MSA-P and PD patients. Thirty-eight MSA-P patients and 32 PD patients were selected to participate in our electrophysiological investigations. The Keypoint EMG/EP system was used to induce the BCR, and latencies and amplitudes were recorded for systematic statistical analyses. Area under the curve of the receiver operating characteristic was used to assess the specificity and sensitivity of the BCR parameters. A BCR was elicited in 76.32% of MSA-P patients and 93.75% of PD patients. The BCR latencies of the MSA-P group were longer than those of the PD group (p < 0.001). In addition, the MSA-P group had a lower BCR amplitude compared to the PD and control groups (p < 0.001). We discovered the difference between MSA-P and PD through BCR latencies and amplitudes. Compared to PD patients, MSA-P patients have longer latencies and lower amplitudes. Therefore, the BCR may be used to discriminate between MSA-P and PD in some cases.
基金：
This work was funded by the Undergraduate Innovation Project of WMU (No. wyx2016101006).
第一作者机构：[1]Department of Neurology, Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China,[2]Department of Neurology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China,
推荐引用方式(GB/T 7714)：
Huan-jie Huang,Xing-yu Zhu,Xun Wang,et al.The Bulbocavernosus Reflex in the Differential Diagnosis of Multiple System Atrophy with Predominant Parkinsonism and Parkinson's Disease[J].FRONTIERS IN NEUROLOGY.2018,8(JAN):697.doi:10.3389/fneur.2017.00697.
APA：
Huan-jie Huang,Xing-yu Zhu,Xun Wang,Zhang-yang Wang,Wan-li Zhang...&Chun-feng Liu.(2018).The Bulbocavernosus Reflex in the Differential Diagnosis of Multiple System Atrophy with Predominant Parkinsonism and Parkinson's Disease.FRONTIERS IN NEUROLOGY,8,(JAN)
MLA：
Huan-jie Huang,et al."The Bulbocavernosus Reflex in the Differential Diagnosis of Multiple System Atrophy with Predominant Parkinsonism and Parkinson's Disease".FRONTIERS IN NEUROLOGY 8..JAN(2018):697
