机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, P.R. China[2]Department of Neurology, Tengzhou Central People’s Hospital, Zaozhuang 277500, P.R. China[3]Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, P.R. China[4]Centre for Big Data Research in Health, University of New South Wales, Sydney, NSW, Australia[5]The George Institute for Global Health, University of New South Wales, Sydney 2050, NSW, Australia[6]Institutes of Neuroscience, Soochow University, Suzhou 215123, P.R. China
Background: The impact of Total Bile Acids (TBA) level on clinical outcomes after acute Intracerebral Hemorrhage (ICH) is still not understood. Objective: We investigated whether admission TBA level is associated with hematoma volume, stroke clinical severity, and 3-month outcomes in acute ICH patients. Methods: A total of 335 ICH patients were prospectively enrolled. Patients were divided into four groups, according to the quartiles of serum TBA level at the time of admission. Three-month outcomes were evaluated by interviews with patients or their family members. Results: The median hematoma volumes for the quartiles of TBA level (Q1 to Q4) were 12.0, 12.3, 10.0, and 6.7 mL (P<0.001) and the median National Institutes of Health Stroke Scale (NIHSS) scores were 8, 8, 6, and 5 (P=0.002), respectively. In the adjusted models, patients in the highest quartile (Q4) had smaller hematoma volumes (P=0.039) and lower NIHSS scores (P=0.037) than patients in Q1. At three months follow-up, there were 136 patients with poor outcomes (defined as having modified Rankin Scale scores >= 3) and 46 cases of all-cause deaths. TBA level was not significantly associated with poor outcome nor all-cause death after adjusting for age, sex, hematoma volume, and baseline NIHSS(all P-trend >= 0.380). Conclusions: Higher admission TBA was associated with smaller hematoma volume and decreased clinical severity, but not three month outcomes in patients with acute ICH.
基金：
This work was supported in part by grants from the National
Natural Science Foundation of China (81471195),
Basic research of Suzhou Medical and health care (SYS
201724), Suzhou Clinical Research Center of Neurological
Disease (Szzx201503), the Second Affiliated Hospital of
Soochow University Preponderant Clinic Discipline Group
Project Funding (XKQ2015002).
第一作者机构：[1]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, P.R. China
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurology, Second Affiliated Hospital of Soochow University, No.1055, Sanxiang Road, 215004, Suzhou, Jiangsu Province, P.R. China
推荐引用方式(GB/T 7714)：
Kaili Wang,Yu Zhang,Chongke Zhong,et al.Increased Serum Total Bile Acids can be Associated with a Small Hematoma Volume and Decreased Clinical Severity During Acute Intracerebral Hemorrhage[J].CURRENT NEUROVASCULAR RESEARCH.2018,15(2):158-163.doi:10.2174/1567202615666180516114211.
APA：
Kaili Wang,Yu Zhang,Chongke Zhong,Danni Zheng,Jiaping Xu...&Yongjun Cao.(2018).Increased Serum Total Bile Acids can be Associated with a Small Hematoma Volume and Decreased Clinical Severity During Acute Intracerebral Hemorrhage.CURRENT NEUROVASCULAR RESEARCH,15,(2)
MLA：
Kaili Wang,et al."Increased Serum Total Bile Acids can be Associated with a Small Hematoma Volume and Decreased Clinical Severity During Acute Intracerebral Hemorrhage".CURRENT NEUROVASCULAR RESEARCH 15..2(2018):158-163
