机构：[1]Department of Neurology, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou City, Jiangsu 215004, China[2]Institute of Neuroscience, Soochow University, Suzhou City, Jiangsu 215123, China[3]Department of Psychiatry, Guangji Hospital, Suzhou City, Jiangsu 215000, China[4]Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA[5]Department of Neurology, Suzhou Kowloon Hospital, Suzhou City 215028, China
Major depressive disorder (MDD) is one of the leading forms of psychiatric disorders, characterized by aversion to mobility, neurotransmitter deficiency, and energy metabolic decline. Low-level laser therapy (LLLT) has been investigated in a variety of neurodegenerative disorders associated with mitochondrial dysfunction and functional impairments. The goal of this study was to examine the effect of LLLT on depression-like behaviors and to explore the potential mechanism by detecting mitochondrial function following LLLT. Depression models in space restriction mice and Abelson helper integration site-1 (Ahi1) knockout (KO) mice were employed in this work. Our results revealed that LLLT effectively improved depression-like behaviors, in the two depression mice models, by decreasing immobility duration in behavioral despair tests. In addition, ATP biosynthesis and the level of mitochondrial complex IV expression and activity were significantly elevated in prefrontal cortex (PFC) following LLLT. Intriguingly, LLLT has no effects on ATP content and mitochondrial complex I-IV levels in other tested brain regions, hippocampus and hypothalamus. As a whole, these findings shed light on a novel strategy of transcranial LLLT on depression improvement by ameliorating neurotransmitter abnormalities and promoting mitochondrial function in PFC. The present work provides concrete groundwork for further investigation of LLLT for depression treatment.
基金：
This study was supported by the grants from
National Natural Science Foundation of China (81071095, 81120108011,
and 81200893); Jiangsu Province Science and Technology Project
(BK20151197), Suzhou Science and Technology Project (SYS201372
and LCZX201316); the Priority Academic Program Development of
Jiangsu Higher Education Institutions of China; and a Research Grant
NS086929 from the National Institute of Neurological Disorders and
Stroke, National Institutes of Health, USA.
第一作者机构：[1]Department of Neurology, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou City, Jiangsu 215004, China[2]Institute of Neuroscience, Soochow University, Suzhou City, Jiangsu 215123, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou City, Jiangsu 215004, China[2]Institute of Neuroscience, Soochow University, Suzhou City, Jiangsu 215123, China[4]Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, 1120 15th Street, Augusta, GA 30912, USA
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