It is generally known that the human genome makes a large amount of noncoding RNAs compared with coding genes. Long non-coding RNAs (lncRNAs) which composed of more than 200 nucleotides have been described as the largest subclass of the noncoding transcriptome in human noncoding RNAs. Existing research shows that lncRNAs exerted biological functions in various tumors via participating in both oncogenic and tumor suppressing pathways. The previous studies indicated that lncRNA taurine upregulated 1 (TUG1) play important roles in the initiation and progression of malignancies. In this study, based on previous research, we investigated the expression and biological role of the lncRNA-TUG1. We analyzed the relationship between lncRNA-TUG1and endometrial carcinoma (EC) in a total 104 EC carcinoma specimens, compared with that in normal tissues. We found that lncRNA-TUG1 expression in cancer tissues was significantly higher than that in adjacent tissues. Through a series of experiments, the results demonstrated that lncRNA-TUG1 enhances the evolution and progression of EC through inhibiting miR-299 and miR-34a-5p.
基金：
Jiangsu Province's Maternal and child health research [F201548]; Soochow university preponderant clinic discipline group [XKQ2015005, XKQ2015007]
第一作者机构：[1]Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu, China.
通讯作者：
通讯机构：[1]Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu, China.
推荐引用方式(GB/T 7714)：
Liu Lifen,Chen Xin,Zhang Ying,et al.Long non-coding RNA TUG1 promotes endometrial cancer development via inhibiting miR-299 and miR-34a-5p[J].ONCOTARGET.2017,8(19):31386-31394.doi:10.18632/oncotarget.15607.
APA：
Liu, Lifen,Chen, Xin,Zhang, Ying,Hu, Yanrong,Shen, Xiaoqing&Zhu, Weipei.(2017).Long non-coding RNA TUG1 promotes endometrial cancer development via inhibiting miR-299 and miR-34a-5p.ONCOTARGET,8,(19)
MLA：
Liu, Lifen,et al."Long non-coding RNA TUG1 promotes endometrial cancer development via inhibiting miR-299 and miR-34a-5p".ONCOTARGET 8..19(2017):31386-31394
医学