机构：[a]Department of Ultrasound Diagnosis, Kunshan Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu, China[b]Department of Radiology Diagnosis, Kunshan Hospital Affiliated to Jiangsu University, Kunshan,Jiangsu, China[c]Department of Radiology, The Second Affiliated Hospital of Soochow University, Institute of Radiotherapy & Oncology, Soochow University, Suzhou, China
OBJECTIVE: The purpose of this study was to evaluate the clinical value of transvaginal elastography (TVES) combined with high-resolution transvaginal ultrasound (TVS) in the detection of parametrial invasion in cervical cancer and to compare the diagnostic performance with magnetic resonance imaging (MRI). MATERIALS AND METHODS: 52 women with histologically confirmed cervical cancer over a 2-year period were staged using International Federation of Gynecology and Obstetrics (FIGO) criteria and underwent MRI and TVES combined with TVS according to a standardized protocol before treatment. When assessing parametrial involvement with TVS, MRI, and combination of TVES and TVS, the findings were recorded and compared with histopathological results after surgery in early-stage disease (stage <= IIa). Sensitivity, specificity accuracy, positive predictive value (PPV) and negative predictive value (NPV) were calculated for each method independently; subsequently, a matched-sample analysis was performed by using McNemar's test or chi-square test. RESULTS: Of 52 patients, 39 were early-stage disease (stage <= IIa), and 13 were advanced-stage disease (stage >= IIb) according to conventional FIGO staging. For the detection of parametrial infiltration, both the diagnostic sensitivity of MRI and the combination of TVS and TVES were statistically higher than alone TVS in early-stage of cervical cancer (P =0.03 < 0.05). Both MRI and the combination of TVS and TVES had a sensitivity of 72.73%; specificity rates of 82.14% for MRI and 78.57% for the combination of TVES and TVS; and the diagnostic accuracy rates of 79.49% for MRI and 76.92% for the combination of TVES and TVS. A matched sample analysis revealed no statistically significant difference between the diagnostic performance of MRI and the combination of TVES and TVS in the assessment of parametrial invasion (all P values > 0.05). CONCLUSION: TVES combined with TVS performed by a dedicated gynecologic radiologist should be considered a promising and economic method for pre-operative work-up for cervical cancer.
基金：
This work is supported by the clinical science and technology development fund project of Jiangsu
University (JLY20160050).
第一作者机构：[a]Department of Ultrasound Diagnosis, Kunshan Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu, China
通讯作者：
通讯机构：[*1]Department of Radiology Diagnosis, Kunshan Hospital Affiliated to Jiangsu University, qianjin road 91, Kunshan, Jiangsu, China.[*2]Department of Radiology, The Second Affiliated Hospital of Soochow University, Institute of Radiotherapy & Oncology, Soochow University, Sanxiang Road 1055, Suzhou, Jiangsu, China.
推荐引用方式(GB/T 7714)：
Xi Ma,Qi Li,Jian-liang Wang,et al.Comparison of elastography based on transvaginal ultrasound and MRI in assessing parametrial invasion of cervical cancer[J].CLINICAL HEMORHEOLOGY AND MICROCIRCULATION.2017,66(1):27-35.doi:10.3233/CH-16235.
APA：
Xi Ma,Qi Li,Jian-liang Wang,Jun Shao,Yu-chun Zhu...&Jun-kang Shen.(2017).Comparison of elastography based on transvaginal ultrasound and MRI in assessing parametrial invasion of cervical cancer.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,66,(1)
MLA：
Xi Ma,et al."Comparison of elastography based on transvaginal ultrasound and MRI in assessing parametrial invasion of cervical cancer".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 66..1(2017):27-35
