机构：[1]Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China,[2]Department of Oncology, the Second Affiliated Hospital of Soochow University, Suzhou, China,[3]Division of Medical Genetics, Maternal and Child Health Hospital of Hunan Province, Changsha, China, and[4]Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Disease, Soochow University, Suzhou, China
Epidemiologic evidence has shown inconsistent findings regarding the relationships between abdominal fatness, as measured by waist circumferences (WC) or waist-to-hip ratio (WHR), and risks of pre- and postmenopausal breast cancer (BC). A dose-response meta-analysis of prospective studies was conducted to address these issues. Potentially eligible studies were identified by searching PubMed and EMBASE databases, and by carefully reviewing the bibliographies of retrieved publications and related reviews. The summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated using a random-effects model. When the most fully adjusted RRs were combined, both WC (14 studies, RR (per 10-cm increase)=1.06, 95% CI: 1.04-1.09, I-2=29.9%) and WHR (15 studies, RR (per 0.1-unit increase)=1.07, 95% CI: 1.01-1.14, I-2=52.9%) were significantly positively associated with postmenopausal BC, but neither WC (eight studies, RR (per 10-cm increase)=1.05, 95% CI: 0.99-1.10, I-2=0%) nor WHR (11 studies, RR (per 0.1-unit increase)=1.07, 95% CI: 0.95-1.21, I-2=59.7%) were associated with premenopausal BC. The WHR-postmenopausal BC association lost statistical significance after correcting publication bias (RR (per 0.1-unit increase)=1.06, 95% CI: 0.99-1.13). When considering BMI-adjusted RRs, WC was associated with both pre- (five studies, RR (per 10-cm increase)=1.09, 95% CI: 1.02-1.16, I-2=0%) and postmenopausal BC (seven studies, RR (per 10-cm increase)=1.05, 95% CI: 1.02-1.08, I-2=6.3%), whereas WHR was not associated with either pre- (seven studies, RR (per 0.1-unit increase)=1.12, 95% CI: 0.94-1.34, I-2=70.9%) or postmenopausal BC (eight studies, RR (per 0.1-unit increase)=1.05, 95% CI: 0.98-1.13, I-2=57.3%). Among non-current (former or never) users of hormone replacement therapy, the summary RR (per 10-cm increase) of postmenopausal BC associated with WC was 1.08 (95% CI: 1.03-1.05, I-2=69.2%, seven studies; BMI-adjusted RR=1.05, 95% CI: 1.02-1.09, I-2=22.8%, four studies). This meta-analysis indicates that central obesity measured by WC, but not by WHR, is associated with modestly increased risks of both pre- and postmenopausal BC independent of general obesity.
基金：
The current study was supported in part by the Second
Affiliated Hospital of Soochow University Clinical
Discipline Group Project Funding (XKQ 2015008)
awarded to Y.-S. Z.’s research group.
第一作者机构：[1]Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China,
通讯作者：
通讯机构：[*1]Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Dushu Lake Higher Education Town, Suzhou 215123, China.[*2]Department of Oncology, the Second Hospital of Soochow University, 1055 Sanxiang Road, Jincan District, Suzhou 215004, China.
推荐引用方式(GB/T 7714)：
G. -C. Chen ,S. -J. Chen ,R. Zhang ,et al.Central obesity and risks of pre- and postmenopausal breast cancer: a dose-response meta-analysis of prospective studies[J].OBESITY REVIEWS.2016,17(11):1167-1177.doi:10.1111/obr.12443.
APA：
G. -C. Chen,,S. -J. Chen,,R. Zhang,,K. Hidayat,,J. -B. Qin,...&L. -Q. Qin.(2016).Central obesity and risks of pre- and postmenopausal breast cancer: a dose-response meta-analysis of prospective studies.OBESITY REVIEWS,17,(11)
MLA：
G. -C. Chen,,et al."Central obesity and risks of pre- and postmenopausal breast cancer: a dose-response meta-analysis of prospective studies".OBESITY REVIEWS 17..11(2016):1167-1177
医学
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