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The association between normal BMI with central adiposity and proinflammatory potential immunoglobulin G N-Glycosylation

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收录情况： ◇ SCIE

作者：
Di Liu,[1] * ; Qihuan Li,[1,2] * ; Jing Dong,[3] ; Dong Li,[4] ; Xizhu Xu,[4] ; Weijia Xing,[4] ; Xiaoyu Zhang,[1] ; Weijie Cao,[1] ; Haifeng Hou,[4] ; HaoWang,[1,5] ; Manshu Song, [1] ; Lixin Tao,[1] ; Xiaoping Kang,[6] ; Qun Meng,[1] ; WeiWang, [1,4,5] ; Xiuhua Guo,[1,*2] ; YouxinWang [1,*1] ;
机构： [1]Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, People’s Republic of China [2]Meinian Institute of Health, Beijing 100191, People’s Republic of China [3]Center for Physical Examination, Xuanwu Hospital, Capital Medical University, Beijing 100050, People’s Republic of China [4]School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, Shandong Province, People’s Republic of China [5]School of Medical and Health Sciences, Edith Cowan University, Perth 6027, Australia [6]The Rehabilitation Center, Beijing Xiaotangshan Hospital, Beijing 102211, People’s Republic of China
出处：
DOI： 10.2147/DMSO.S216318
ISSN：

关键词： BMI Body mass index Immunoglobulin G N-glycan N-glycosylation Normal BMI with central adiposity Waist-to-hip ratio WHR

摘要：
Background: The mechanism by which normal body mass index (BMI) with central adiposity (NWCA) increases the risk of the diseases has not been completely elucidated. The inflammatory role of immunoglobulin G (IgG) N-glycosylation in obesity defined by BMI or central adiposity defined by waist-to-hip ratio (WHR) was reported, respectively. We undertook this three-center cross-sectional study to determine the association between the IgG N-glycans and NWCA. Methods: The participants were categorized into four different phenotypes: normal BMI with normal WHR (NW), normal BMI with central adiposity (NWCA), obesity with normal WHR (ONCA) and obesity with central adiposity (OCA). The IgG N-glycans were analyzed using ultra-performance liquid chromatography analysis of released glycans, and differences among groups were compared. Results: In total, 17 out of 24 initial IgG N-glycans were significantly different among the four groups (NW, ONCA, NWCA and OCA) (P<0.05/6*78=0.0001). The changes of IgG glycans in central obesity (12 GPs) were more than those in obesity (3 GPs). In addition, lower galactosylation and bisecting GlcNAc and higher fucosylation were associated with increased risk of NWCA. Conclusion: Central obesity was involved in more changes of IgG N-glycosylation representing stronger inflammation than obesity, which might make a greater contribution to the risk of related disorders. NWCA was associated with an increased pro-inflammatory of IgG N-glycosylation, which was accompanied by the development of central obesity and other related disorders. © 2019 Liu et al.

基金：
This work was supported by grants from National Natural Science Foundation of China (81673247, 81530087, 81872682 and 81773527) and Joint Project of the Australian National Health & Medical Research Council (NHMRC) and the NSFC (NH&MRC-APP1112767 –NSFC81561128020).
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外文
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中科院(CAS)分区：
出版当年[2018]版：
大类 | 3 区 医学
小类 | 3 区 内分泌学与代谢
最新[2023]版：
大类 | 3 区 医学
小类 | 4 区 内分泌学与代谢
JCR分区：
出版当年[2017]版：
Q3 ENDOCRINOLOGY & METABOLISM
最新[2023]版：
Q3 ENDOCRINOLOGY & METABOLISM

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [1]Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构： [1]Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, People’s Republic of China [*1]School of Public Health, Capital Medical University, 10 Youanmen Xitoutiao, Beijing 100069, People’s Republic of China [*2]School of Public Health, Capital Medical University, 10 Youanmen Xitoutiao, Beijing 100069, People’s Republic of China
推荐引用方式(GB/T 7714)：
Di Liu ,Qihuan Li ,Jing Dong ,et al.The association between normal BMI with central adiposity and proinflammatory potential immunoglobulin G N-Glycosylation[J].DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY.2019,12:2373-2385.doi:10.2147/DMSO.S216318.
APA：
Di Liu,,Qihuan Li,,Jing Dong,,Dong Li,,Xizhu Xu,...&YouxinWang.(2019).The association between normal BMI with central adiposity and proinflammatory potential immunoglobulin G N-Glycosylation.DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY,12,
MLA：
Di Liu,,et al."The association between normal BMI with central adiposity and proinflammatory potential immunoglobulin G N-Glycosylation".DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY 12.(2019):2373-2385

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