机构：[1]Center for Systems Biology, Soochow University, Suzhou 215006, China[2]School of Chemistry, Biological Engineering, Suzhou University of Science and Technology, Suzhou 215011, China[3]Suzhou Dushuhu Hospital, Clinic Center, Soochow University, Suzhou 215123, China[4]Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China[5]Ningbo Urologic and Nephrotic Hospital, Ningbo 315000, China.
Early diagnosis and surveillance for metastasis and recurrences are critical issues of urologic cancer. Deregulation of long non-coding RNAs (lncRNAs) has been implicated in urologic malignancies and represents potential markers or therapeutic targets. However, the utility of lncRNA as biomarkers appears to be overstated due to heterogeneous or irreproducible results from different studies. Thus, a critical and cautious review on the biomarker potential of lncRNAs is needed. This review provides an update on new findings of lncRNA-based markers for urologic cancer. The diverse mechanisms and associated examples of lncRNAs involved during the carcinogenesis of prostate cancer, bladder cancer and renal cancer were discussed in a more balanced and critical manner, as were the suitability of lncRNAs as diagnostic or prognostics markers.
基金：
This work was supported by the National
Natural Science Foundation of China grants
(31400712, 31470821, 91530320) and Technology R&D
Program of Suzhou (SYN201409).
第一作者机构：[1]Center for Systems Biology, Soochow University, Suzhou 215006, China[2]School of Chemistry, Biological Engineering, Suzhou University of Science and Technology, Suzhou 215011, China
通讯作者：
通讯机构：[1]Center for Systems Biology, Soochow University, Suzhou 215006, China
推荐引用方式(GB/T 7714)：
Jiajia Chen,Zhijun Miao,Boxin Xue,et al.Long Non-coding RNAs in Urologic Malignancies: Functional Roles and Clinical Translation[J].JOURNAL OF CANCER.2016,7(13):1842-1855.doi:10.7150/jca.15876.
APA：
Jiajia Chen,Zhijun Miao,Boxin Xue,Yuxi Shan,Guobin Weng&Bairong Shen.(2016).Long Non-coding RNAs in Urologic Malignancies: Functional Roles and Clinical Translation.JOURNAL OF CANCER,7,(13)
MLA：
Jiajia Chen,et al."Long Non-coding RNAs in Urologic Malignancies: Functional Roles and Clinical Translation".JOURNAL OF CANCER 7..13(2016):1842-1855
