机构：[1]Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.[2]Department of Neurology, The Second Affiliated Hospital &Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.[3]Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.[4]Center of Biomedical Research Excellence, College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.[5]The Central Laboratory, Shenzhen Key Laboratory of Neurosurgery, and the Department of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen University First Affiliated Hospital, Shenzhen, China.
The hippocampus receives dopaminergic projections from the ventral tegmental area (VTA) and substantia nigra. These inputs appear to provide a modulatory signal that influences hippocampus-dependent behaviors. Enhancements in working memory performance have been previously reported following acute smoking/nicotine exposure. However, the underlying mechanism remains unclear. This study investigated the effects of nicotine on spatial working memory (SWM) and the mechanisms involved. Delayed alternation T-maze task was used to assess SWM. In situ and gel gelatin zymography were used to detect matrix metalloproteinase-9 (MMP-9) in SWM. Systemic or local (intra-VTA) administration of nicotine significantly improves SWM, which was accompanied by increased MMP-9 activity in dorsal hippocampus (dHPC). Intra-dHPC administration of MMP inhibitor FN-439 abolished the memory enhancement induced by intra-VTA nicotine infusion. FN-439 had no effect on locomotor behavior. Our data suggest that intra-VTA nicotine infusion activates MMP-9 in dHPC to improve SWM in rats.
基金：
This work was supported by Soochow University Research starting
funds to Jin X (Q 421500113), by Doctoral Fund of Ministry of
Education of China to Jin X (K521507713).This work was also supported by the Priority Academic Program Development of
Jiangsu Higher Education Institutions of China and Shenzhen Key
Laboratory of Neurosurgery Award from Shenzhen Science and
Technology Innovation Commission (ZDSYS20140509173142
601).
第一作者机构：[1]Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases and Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
通讯作者：
通讯机构：[*1]Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou 215004, China.[*2]The Central Laboratory of Shenzhen Second People’s Hospital, Shenzhen University First Affiliated Hospital, Shenzhen 518035, China
推荐引用方式(GB/T 7714)：
Shu Hui,Zheng Guo-qing,Wang Xiaona,et al.Activation of matrix metalloproteinase in dorsal hippocampus drives improvement in spatial working memory after intra-VTA nicotine infusion in rats[J].JOURNAL OF NEUROCHEMISTRY.2015,135(2):357-67.doi:10.1111/jnc.13283.
APA：
Shu, Hui,Zheng, Guo-qing,Wang, Xiaona,Sun, Yanyun,Liu, Yushan...&Jin, Xinchun.(2015).Activation of matrix metalloproteinase in dorsal hippocampus drives improvement in spatial working memory after intra-VTA nicotine infusion in rats.JOURNAL OF NEUROCHEMISTRY,135,(2)
MLA：
Shu, Hui,et al."Activation of matrix metalloproteinase in dorsal hippocampus drives improvement in spatial working memory after intra-VTA nicotine infusion in rats".JOURNAL OF NEUROCHEMISTRY 135..2(2015):357-67
医学