Caffeic acid phenethyl ester attenuates ionize radiation-induced intestinal injury through modulation of oxidative stress, apoptosis and p38MAPK in rats
机构：[a]Department of Surgery, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China[b]Department of Oncology, The Affiliated Hospital of Jiangnan University, 200 Huihe Road, 214122 Wuxi, China[c]Wuxi Medical School, Jiangnan University, 1800 Lihu Road, 214122 Wuxi, China
Caffeic acid phenyl ester (CAPE) is a potent anti-inflammatory agent and it can eliminate the-free radicals. This study aimed to investigate the radioprotective effects of CAPE on X-ray irradiation induced intestinal injury in rats. Rats were intragastrically administered with 10 mu mol/kg/d CAPE for 7 consecutive days before exposing them to a single dose of X-ray irradiation (9 Gy) to abdomen. Rats were sacrificed 72 h after exposure to radiation. We found that pretreatment with CAPE effectively attenuated intestinal pathology changes, apoptosis, oxidative stress, bacterial translocation, the content of nitric oxide and myeloperoxidase as well as the concentration of plasma tumor necrosis factor-a. Pretreatment with CAPE also reversed the activation of p38MAPK and the increased expression of intercellular cell adhesion molecule-1 induced by radiation in intestinal mucosa. Taken together, these results suggest that pretreatment with CAPE could be a promising candidate for treating radiation-induced intestinal injury. (C) 2015 Elsevier B.V. All rights reserved.
基金：
This work was supported by the following grant: the NationalNatural Science Foundation of China (81270126), the Fundamen-tal Research Funds for the Central Universities (JUSRP51412B), theWuxi hospital management key program (yGzxl 1314) and theJiangnan university Students Innovation Training (2014317).
第一作者机构：[a]Department of Surgery, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China
通讯作者：
通讯机构：[a]Department of Surgery, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, 215004 Suzhou, China
推荐引用方式(GB/T 7714)：
Liu-gen Jin,Jian-Jun Chu,Qing-feng Pang,et al.Caffeic acid phenethyl ester attenuates ionize radiation-induced intestinal injury through modulation of oxidative stress, apoptosis and p38MAPK in rats[J].ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY.2015,40(1):156-63.doi:10.1016/j.etap.2015.05.012.
APA：
Liu-gen Jin,Jian-Jun Chu,Qing-feng Pang,Fu-zheng Zhang,Gang Wu...&Chun-gen Xing.(2015).Caffeic acid phenethyl ester attenuates ionize radiation-induced intestinal injury through modulation of oxidative stress, apoptosis and p38MAPK in rats.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,40,(1)
MLA：
Liu-gen Jin,et al."Caffeic acid phenethyl ester attenuates ionize radiation-induced intestinal injury through modulation of oxidative stress, apoptosis and p38MAPK in rats".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 40..1(2015):156-63
