机构：[1]Department of Plastic Surgery, the Second Affiliated Hospital, Soochow University, Suzhou 215004, China[2]Department of Pathology, School of Biology & Basic Medical Sciences, Soochow University, Suzhou 215123, China[3]College of Pharmaceutical Science, Soochow University, Suzhou 215123, China[4]Department of Pathology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China[5]Institute of Radiology & Oncology, Soochow University, Suzhou 215006, China[6]Suzhou Key Laboratory of Tumor Microenvironment Pathology, Suzhou 215123, China
Radiation-induced skin injury, which remains a serious concern in radiation therapy, is currently believed to be the result of vascular endothelial cell injury and apoptosis. Here, we established a model of acute radiation-induced skin injury and compared the effect of different vascular growth factors on skin healing by observing the changes of microcirculation and cell apoptosis. Vascular endothelial growth factor (VEGF) was more effective at inhibiting apoptosis and preventing injury progression than other factors. A new strategy for improving the bioavailability of vascular growth factors was developed by loading VEGF with chitosan nanoparticles. The VEGF-chitosan nanoparticles showed a protective effect on vascular endothelial cells, improved the local microcirculation, and delayed the development of radioactive skin damage.
基金：
This work was supported in part by Chinese Nature Science Foundation (81272738,
81372867, 81472297) and Project Founded by the Priority Academic Program Development of Jiangsu Higher
Education Institutions.
第一作者机构：[1]Department of Plastic Surgery, the Second Affiliated Hospital, Soochow University, Suzhou 215004, China[2]Department of Pathology, School of Biology & Basic Medical Sciences, Soochow University, Suzhou 215123, China
共同第一作者：
通讯作者：
通讯机构：[2]Department of Pathology, School of Biology & Basic Medical Sciences, Soochow University, Suzhou 215123, China[3]College of Pharmaceutical Science, Soochow University, Suzhou 215123, China[5]Institute of Radiology & Oncology, Soochow University, Suzhou 215006, China[6]Suzhou Key Laboratory of Tumor Microenvironment Pathology, Suzhou 215123, China
推荐引用方式(GB/T 7714)：
Daojiang Yu,Shan Li,ShuaiWang,et al.Development and Characterization of VEGF165-Chitosan Nanoparticles for the Treatment of Radiation-Induced Skin Injury in Rats[J].MARINE DRUGS.2016,14(10):doi:10.3390/md14100182.
APA：
Daojiang Yu,Shan Li,ShuaiWang,Xiujie Li,Minsheng Zhu...&Shouli Wang.(2016).Development and Characterization of VEGF165-Chitosan Nanoparticles for the Treatment of Radiation-Induced Skin Injury in Rats.MARINE DRUGS,14,(10)
MLA：
Daojiang Yu,et al."Development and Characterization of VEGF165-Chitosan Nanoparticles for the Treatment of Radiation-Induced Skin Injury in Rats".MARINE DRUGS 14..10(2016)
