Differentiation of Glioma Stem Cells and Progenitor Cells into Local Host Cell-Like Cells: A Study Based on Choroidcarcinoma Differentiation of Choroid Plexus of GFP Transgenic Nude Mouse
机构：[1]Department of Neurosurgery, Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Suzhou, China.[2]Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.[3]Department of Pharmaceutical Preparation Section, Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Suzhou, China.
The idea of multiple differentiation capacity of glioma stem cells and progentior cells (GSCPs) has been accepted by most of the researchers, but the effect of local environment on the differentiation of GSCPs is unclear. GSCPs SU2 and CM-Dil-stained C6 cells (C6-Dil) were injected into the brain of GFP transgenic nude mice. The xenografts were sectioned. Morphological changes of tumor cells that resided in the choroid plexus, molecular markers expression, and the relationship between the original tumor cells and host cells were studied carefully. The tumorigenicity rate was 40/40 (100%) in all of the inoculated nude mice. Cell morphology and molecular expression of neoplasm settled in the choroid plexus showed that choroidcarcinoma derived from GSCPs was developed. These results showed that GSCPs may have the multiple differentiation capacity, which can be induced by the local environment of host brain as NSCs, and cell fusion may play an important role in the transformation.
基金：
This work was funded by grants from the Natural Science
Foundation of China (No. 81302196; 81172400; 81071766;
81472739), the Natural Science Foundation of Jiangsu Province
(No. BK2011341), and the Natural Science Foundation
of Suzhou (No. SYS201307).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区肿瘤学4 区药学4 区核医学
最新[2023]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区肿瘤学4 区药学4 区核医学
JCR分区：
出版当年[2013]版：
Q3MEDICINE, RESEARCH & EXPERIMENTALQ3RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ3PHARMACOLOGY & PHARMACYQ4ONCOLOGY
最新[2023]版：
Q2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ3MEDICINE, RESEARCH & EXPERIMENTALQ3ONCOLOGYQ3PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Neurosurgery, Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Suzhou, China.
共同第一作者：
通讯作者：
通讯机构：[*1]Department of Neurosurgery, The Second Affiliated Hospital of Soochow University,No. 1055, Sanxiang Road, Suzhou, Jiangsu 215004, China
推荐引用方式(GB/T 7714)：
Zhimin Wang,Xifeng Fei,Xinliang Dai,et al.Differentiation of Glioma Stem Cells and Progenitor Cells into Local Host Cell-Like Cells: A Study Based on Choroidcarcinoma Differentiation of Choroid Plexus of GFP Transgenic Nude Mouse[J].CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS.2015,30(5):225-32.doi:10.1089/cbr.2014.1722.
APA：
Zhimin Wang,Xifeng Fei,Xinliang Dai,Hanchun Chen,Haiyan Tian...&Qiang Huang.(2015).Differentiation of Glioma Stem Cells and Progenitor Cells into Local Host Cell-Like Cells: A Study Based on Choroidcarcinoma Differentiation of Choroid Plexus of GFP Transgenic Nude Mouse.CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS,30,(5)
MLA：
Zhimin Wang,et al."Differentiation of Glioma Stem Cells and Progenitor Cells into Local Host Cell-Like Cells: A Study Based on Choroidcarcinoma Differentiation of Choroid Plexus of GFP Transgenic Nude Mouse".CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS 30..5(2015):225-32
