机构：[a]Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, San Xiang Road No. 1055, Suzhou 215004[b]Department of Radiotherapy and Oncology, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong 226001[c]Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province 215006[d]Department of Neurosurgery, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong 226001[e]Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Medical College of Nantong University, Nantong, Jiangsu Province 226001[f]Department of Pathology, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong 226001
Previous studies have demonstrated that FoxJ2 (forkhead box J2) is a member of Forkhead Box transcription factors and acts as an important prognostic indicator in human breast cancer. Our study aimed to assess the expression and function in human glioma. Western blot analysis and immunohistochemistry were performed in human glioma tissues. Low FoxJ2 expression was observed in 80 samples and its level was correlated with the grade of malignancy. A strongly positive correlation was observed between FoxJ2 and E-cadherin. Overexpression of FoxJ2 increased E-cadherin expression and decreased vimentin expression. The wound healing and transwell assays showed that overexpression of FoxJ2 significantly inhibited their migration in U87 cells. Consistent with this, knockdown of FoxJ2 promoted cellular motility. In a word, FoxJ2 suppressed cell migration and invasion in glioma, which might be a potential novel molecular targeted therapy for surgery and immune treatment. (C) 2015 Elsevier GmbH. All rights reserved.
基金：
Funded by Jiangsu Provincial Special Program of Clinical MedicalScience (BL2014040).
第一作者机构：[a]Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, San Xiang Road No. 1055, Suzhou 215004[b]Department of Radiotherapy and Oncology, The Affiliated Hospital of Nantong University, Xisi Road No. 20, Nantong 226001
通讯作者：
通讯机构：[a]Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, San Xiang Road No. 1055, Suzhou 215004
推荐引用方式(GB/T 7714)：
Xiaojun Qiu,Bin Ji,Lixiang Yang,et al.The role of FoxJ2 in the migration of human glioma cells[J].PATHOLOGY RESEARCH AND PRACTICE.2015,211(5):389-97.doi:10.1016/j.prp.2015.01.005.
APA：
Xiaojun Qiu,Bin Ji,Lixiang Yang,Qingfeng Huang,Wei Shi...&Ye Tian.(2015).The role of FoxJ2 in the migration of human glioma cells.PATHOLOGY RESEARCH AND PRACTICE,211,(5)
MLA：
Xiaojun Qiu,et al."The role of FoxJ2 in the migration of human glioma cells".PATHOLOGY RESEARCH AND PRACTICE 211..5(2015):389-97
