机构：[1]Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China[2]Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, China[3]Department of Clinical Pharmacology, The First Affiliated Hospital of Soochow University, Suzhou, China
Rheumatoid arthritis is the most common arthritis and is mainly characterized by symmetric polyarticular joint disorders. Eleutheroside E (EE), a principal active constituent of Acanthopanax senticosus, is reported to have anti-inflammatory effect by inhibiting NF-kappa B activities. However, the effects of EE on rheumatoid arthritis (RA) severity are largely unknown. The purpose of this study was to indicate whether EE could ameliorate arthritis and reduce inflammatory cytokine release in collagen-induced arthritis (CIA) mice. The results showed that EE attenuated the severity of arthritis by reducing the mean arthritis score and arthritis incidence. EE also significantly decreased the inflammatory cell infiltration, pannus formation, cartilage damage, and bone erosion of CIA mice. Furthermore, EE caused a marked decrease of the production of TNF-alpha and IL-6 in vivo and in vitro. These observations identify a novel function of EE that results in inhibition of cytokine release, highlighting EE was a potential therapeutic agent for RA.
基金：
This work was supported by the grants from the
National Natural Science Foundation of China (No.
81202348 and No. 81202394) and Jiangsu Province National
Natural Science Funds (No. BK2012171) and the
Natural Science Research Project of Higher Education of
Jiangsu (No. 12KJD310006), the Applied Basic Research
Programs of Suzhou Sci-tech Bureau (No. SYS201219),
and the Medical Research Projects of Health Department
of Jiangsu Province (No. Z201304).
第一作者机构：[1]Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China[3]Department of Clinical Pharmacology, The First Affiliated Hospital of Soochow University, Suzhou, China
推荐引用方式(GB/T 7714)：
Chunyan He ,Xiaohui Chen ,Chunyang Zhao ,et al.Eleutheroside E Ameliorates Arthritis Severity in Collagen-Induced Arthritis Mice Model by Suppressing Inflammatory Cytokine Release[J].INFLAMMATION.2014,37(5):1533-43.doi:10.1007/s10753-014-9880-7.
APA：
Chunyan He,,Xiaohui Chen,,Chunyang Zhao,,Yanyan Qie,,Zhaowei Yan,&Xueming Zhu.(2014).Eleutheroside E Ameliorates Arthritis Severity in Collagen-Induced Arthritis Mice Model by Suppressing Inflammatory Cytokine Release.INFLAMMATION,37,(5)
MLA：
Chunyan He,,et al."Eleutheroside E Ameliorates Arthritis Severity in Collagen-Induced Arthritis Mice Model by Suppressing Inflammatory Cytokine Release".INFLAMMATION 37..5(2014):1533-43
