机构：[1]Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Suzhou 215004, China[2]Division of Rheumatology, Department of Medicine, NYU Hospital for Joint Diseases, New York University (NYU) School of Medicine, New York, NY 10016, USA[3]Soochow University Orthopaedic Institute, Suzhou 215000, China
Iron accumulation is a risk factor of osteoporosis; mechanisms leading to iron-related bone loss are not fully determined. We sought to better understand the effect of chronic iron accumulation on bone over the life span in a mouse model. Hepcidin1 knockout (Hepc1 (-/-)) male mice and their littermate control wild type (WT) mice at 7 months old were used in this study. Serum iron and ferritin as well as iron contents in liver and femur were significantly increased in Hepc1 (-/-) mice compared to WT mice. We found that Hepc1 (-/-) mice had a phenotype of low bone mass and alteration of the bone microarchitecture, most likely caused by a decreased osteoblastic activity. Cell culture studies indicated that chronic iron accumulation decreased bone formation, probably by affecting bone morphogenetic protein signaling.
基金：
This work was supported by Grants
from the National Natural Science Foundation of China (81273090,
81302438), the Natural Science Foundation of Jiangsu Province
(BK2012608), Research and Innovation Project for College Graduates
of Jiangsu Province (CXZZ12_0845), and the Foundation Program of
Suzhou Key Laboratory of High Technology (SZS201208).
第一作者机构：[1]Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Suzhou 215004, China
通讯作者：
通讯机构：[1]Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Suzhou 215004, China
推荐引用方式(GB/T 7714)：
Shen Guang Si,Yang Qing,Jian Jing Long,et al.Hepcidin1 Knockout Mice Display Defects in Bone Microarchitecture and Changes of Bone Formation Markers[J].CALCIFIED TISSUE INTERNATIONAL.2014,94(6):632-9.doi:10.1007/s00223-014-9845-8.
APA：
Shen, Guang Si,Yang, Qing,Jian, Jing Long,Zhao, Guo Yang,Liu, Lu Lin...&Xu, You Jia.(2014).Hepcidin1 Knockout Mice Display Defects in Bone Microarchitecture and Changes of Bone Formation Markers.CALCIFIED TISSUE INTERNATIONAL,94,(6)
MLA：
Shen, Guang Si,et al."Hepcidin1 Knockout Mice Display Defects in Bone Microarchitecture and Changes of Bone Formation Markers".CALCIFIED TISSUE INTERNATIONAL 94..6(2014):632-9
