机构：[1]Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou 215004,Jiangsu Province, People’s Republic of China[2]Department of Geriatrics, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, Jiangsu Province, People’s Republic of China[3]No. 1055 Sanxiang Road, Suzhou 215004, Jiangsu Province, People’s Republic of China
Magnesium lithospermate B (MLB) is one of the major bioactive components of Radix Salviae miltiorrhizae (Dan Shen), which is a Chinese traditional herbal medicine with therapeutic effects on cardiovascular and cerebrovascular diseases. The aim of this study was to investigate the neuroprotective effects of MLB on N-methyl-d-aspartic acid (NMDA)-injured neurons and against kainic acid (KA)-induced neurodegeration in mice. In cultured mouse primary hippocampal neurons, MLB significantly reduced NMDA-induced cell death and promoted neurite growth in a dose-dependent manner. In FVB mice, MLB attenuated KA-induced neurodegeneration. Additionally, MLB prevented the decrease in phosphorylated Akt and glycogen synthase kinase-3 beta (GSK-3 beta) levels both in NMDA-injured neurons and KA-injured mouse brain. This effect was blocked by phosphoinositide 3-kinase (PI3K) inhibitor LY294002 and Akt inhibitor triciribine, thus indicating the neuroprotective effects of MLB are most likely mediated by the PI3K/Akt/GSK-3 beta pathway. Taken together, these results show the efficacy and underlying mechanism of MLB against neuronal injury and raise its therapeutic potential in neurodegenerative diseases.
第一作者机构：[1]Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou 215004,Jiangsu Province, People’s Republic of China[3]No. 1055 Sanxiang Road, Suzhou 215004, Jiangsu Province, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou 215004,Jiangsu Province, People’s Republic of China[3]No. 1055 Sanxiang Road, Suzhou 215004, Jiangsu Province, People’s Republic of China
推荐引用方式(GB/T 7714)：
Guodong Xiao,Weidong Hu,Xuesong Chen.Magnesium Lithospermate B Protects Neurons from N-Methyl-D-Aspartic Acid Injury and Attenuates Kainic Acid-Induced Neurodegeration in FVB Mice[J].JOURNAL OF MOLECULAR NEUROSCIENCE.2013,51(2):550-7.doi:10.1007/s12031-013-0023-7.
APA：
Guodong Xiao,Weidong Hu&Xuesong Chen.(2013).Magnesium Lithospermate B Protects Neurons from N-Methyl-D-Aspartic Acid Injury and Attenuates Kainic Acid-Induced Neurodegeration in FVB Mice.JOURNAL OF MOLECULAR NEUROSCIENCE,51,(2)
MLA：
Guodong Xiao,et al."Magnesium Lithospermate B Protects Neurons from N-Methyl-D-Aspartic Acid Injury and Attenuates Kainic Acid-Induced Neurodegeration in FVB Mice".JOURNAL OF MOLECULAR NEUROSCIENCE 51..2(2013):550-7
