机构：[1]The Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, China[2]Department of Neurology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, People’s Republic China[3]The Department of Psychiatry, The Fourth People’s Hospital of Nantong, Nantong 226001, Jiangsu, People’s Republic China[4]The Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, China
Tropomyosin (TM), is a coiled-coil dimmer which modulates actin filament properties, has been implicated in the control of actin filament dynamics during cell migration, morphogenesis, and cytokinesis. However, the expressions and possible functions of tropomyosin in central nervous system (CNS) lesion remain unknown. In this study, we found the expression of tropomyosin gradually increased in rat brains subjected to traumatic brain injury (TBI). Double immunofluorescence staining showed tropomyosin was expressed in neurons and reactive astrocytes following TBI but not in quiescent astrocytes in normal brains. Furthermore, we detected that proliferating cell nuclear antigen (PCNA) had the co-localization with GFAP, and tropomyosin. In conclusion, this was the first description of tropomyosin expression in rat traumatic brain. Our date suggested that tropomyosin might be involved in the astrocytes proliferation following TBI.
基金：
This study was supported by the National Natural
Science Foundation of China (No. 81070992) and A Project
Funded by the Priority Academic Program Development of Jiangsu
Higher Education Institutions (PAPD).
第一作者机构：[1]The Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, China[2]Department of Neurology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, People’s Republic China
共同第一作者：
通讯作者：
通讯机构：[2]Department of Neurology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, People’s Republic China[4]The Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, China
推荐引用方式(GB/T 7714)：
Xinmin Wu,Hongran Fu,Feihui Zou,et al.Increased expression of actin filament-stabilizing protein tropomyosin after rat traumatic brain injury[J].JOURNAL OF MOLECULAR HISTOLOGY.2013,44(1):37-45.doi:10.1007/s10735-012-9461-8.
APA：
Xinmin Wu,Hongran Fu,Feihui Zou,Wei Jin,Ting Xu...&Yongjin Pan.(2013).Increased expression of actin filament-stabilizing protein tropomyosin after rat traumatic brain injury.JOURNAL OF MOLECULAR HISTOLOGY,44,(1)
MLA：
Xinmin Wu,et al."Increased expression of actin filament-stabilizing protein tropomyosin after rat traumatic brain injury".JOURNAL OF MOLECULAR HISTOLOGY 44..1(2013):37-45
